摘要
The risk of tamoxifen related endome trial neoplasm has been confirmed by multiple studies.Especially rare en-dometrial tumors seem to develop more frequently under tamoxifen therapy.A recent analysis showed a substantially higher risk for malignant mixed meso dermal tumor(MMMT;designated in the WHO classification of female genital tract neoplasms as carcinosarcoma )in association with tamoxifen intake.We are reporting a case of a 40-year -old multiparous premenopausa l woman who received tamoxifen 20mg daily for 2years afte r the surgical treat-ment of breast cancer and subsequent adjuvant chemother-apy.Two years after initiation of ta moxifen treatment,the patient developed anMMMTof the uterus.More than 64months after radical hysterectomy,salpingo -oophorecto-my,and pelvic lymphadenectomy,she remains recur-rence -free for MMMT.Unfortunately,she developed a local recurrence of her breast cancer in 2003.After surgi-cal treatment,she is currently bein g treated with anastro-zole.We are reporting a rare case of a premenopausal pa-tient who developed a MMMT within short time of tamoxifen exposure for stage I breast cancer.
The risk of tamoxifen related endome trial neoplasm has been confirmed by multiple studies.Especially rare en-dometrial tumors seem to develop more frequently under tamoxifen therapy.A recent analysis showed a substantially higher risk for malignant mixed meso dermal tumor(MMMT;designated in the WHO classification of female genital tract neoplasms as carcinosarcoma )in association with tamoxifen intake.We are reporting a case of a 40-year -old multiparous premenopausa l woman who received tamoxifen 20mg daily for 2years afte r the surgical treat-ment of breast cancer and subsequent adjuvant chemother-apy.Two years after initiation of ta moxifen treatment,the patient developed anMMMTof the uterus.More than 64months after radical hysterectomy,salpingo -oophorecto-my,and pelvic lymphadenectomy,she remains recur-rence -free for MMMT.Unfortunately,she developed a local recurrence of her breast cancer in 2003.After surgi-cal treatment,she is currently bein g treated with anastro-zole.We are reporting a rare case of a premenopausal pa-tient who developed a MMMT within short time of tamoxifen exposure for stage I breast cancer.
