摘要
The purpose of this study was to compare the umbilical arterial 8- iso- prostaglandin F2α ,.concentrations between pregnancies that were complicated by moderate or thick meconium- stained liquor and those with clear liquor. Umbilical cord arterial blood samples were collected from 247 singleton pregnancies with either moderate or thick meconium- stained liquor at any stage of labor or clear liquor at all stages of labor for the determination of the total 8- iso- prostaglandins F2α concentration. The median total 8- iso- prostaglandins F2α concentration of the meco- niumstained liquor group was significantly higher than that of the control group (719.2 vs 115.8 pg/mL). Among the meconiumstained liquor group, those who had a change from "clear liquor" at early labor to "moderate/ thick meconium- stained liquor" at late first stage or at delivery (late meconium- stained liquor group) had higher 8- iso- prostaglandins F2α concentration, compared with those who had moderate/ thick meconiumstained liquor since early labor (early meconium- stained liquor group; 959.8 vs 499.9 pg/mL). With the use of multiple regression analysis, meconium- stained liquor, duration of second stage of labor, and abnormal fetal heart tracings were independent determinants of cord blood 8- iso- prostaglandins F2α concentration. Moderate or thick meconium- stained liquor is an independent factor for increased oxidative stress in pregnancy.
The purpose of this study was to compare the umbilical arterial 8- iso- prostaglandin F2α ,.concentrations between pregnancies that were complicated by moderate or thick meconium- stained liquor and those with clear liquor. Umbilical cord arterial blood samples were collected from 247 singleton pregnancies with either moderate or thick meconium- stained liquor at any stage of labor or clear liquor at all stages of labor for the determination of the total 8- iso- prostaglandins F2α concentration. The median total 8- iso- prostaglandins F2α concentration of the meco- niumstained liquor group was significantly higher than that of the control group (719.2 vs 115.8 pg/mL). Among the meconiumstained liquor group, those who had a change from 'clear liquor' at early labor to 'moderate/ thick meconium- stained liquor' at late first stage or at delivery (late meconium- stained liquor group) had higher 8- iso- prostaglandins F2α concentration, compared with those who had moderate/ thick meconiumstained liquor since early labor (early meconium- stained liquor group; 959.8 vs 499.9 pg/mL). With the use of multiple regression analysis, meconium- stained liquor, duration of second stage of labor, and abnormal fetal heart tracings were independent determinants of cord blood 8- iso- prostaglandins F2α concentration. Moderate or thick meconium- stained liquor is an independent factor for increased oxidative stress in pregnancy.
