摘要
Early diagnosis can improve clinical effects of ovarian carcinoma treatment. U ntil now, a satisfying screening method has not been found. Serum lipid and lipo protein association with neoplasm is already established. In our study, we have examined concentration of total cholesterol, free cholesterol, HDL cholesterol, HDL3 and HDL free cholesterol fraction, triglycerides, and apolipoproteins: AI, AII and B and aimed to prepare the most likely model of lipid profile in women s uffering from ovarian neoplasm. The serum lipid parameters were analysed in 91 o perated patients: 64 with ovarian malignant tumour, 27 with benign ovarian cysts and 44 apparently healthy age-matching pair women as a control group. The resu lts: concentration of two parameters: apolipoprotein AI and free cholesterol all ows for excluding ovarian neoplasm in 95.5%; examination of six parameters: apo lipoprotein AI, free cholesterol, HDL-free cholesterol, HDL total cholesterol, apolipoprotein B and HDL3 fraction allows for diagnosing ovarian malignancy with 97%probability. This probability does not depend on staging of cancer, patient ’s age, nor BMI. No statistically significant difference between malignant and benign ovarian tumour has been confirmed.
Early diagnosis can improve clinical effects of ovarian carcinoma treatment. U ntil now, a satisfying screening method has not been found. Serum lipid and lipo protein association with neoplasm is already established. In our study, we have examined concentration of total cholesterol, free cholesterol, HDL cholesterol, HDL3 and HDL free cholesterol fraction, triglycerides, and apolipoproteins: AI, AII and B and aimed to prepare the most likely model of lipid profile in women s uffering from ovarian neoplasm. The serum lipid parameters were analysed in 91 o perated patients: 64 with ovarian malignant tumour, 27 with benign ovarian cysts and 44 apparently healthy age-matching pair women as a control group. The resu lts: concentration of two parameters: apolipoprotein AI and free cholesterol all ows for excluding ovarian neoplasm in 95.5%; examination of six parameters: apo lipoprotein AI, free cholesterol, HDL-free cholesterol, HDL total cholesterol, apolipoprotein B and HDL3 fraction allows for diagnosing ovarian malignancy with 97%probability. This probability does not depend on staging of cancer, patient 's age, nor BMI. No statistically significant difference between malignant and benign ovarian tumour has been confirmed.
