摘要
Background. Inflammatory mediators participate in the pathogenesis an d pathop hysiology of skin disease (e.g. eczema). Although some investigators have sugges ted that serotoninmay participate in the eczematous process, there has been litt le substantial evidence. Our objectivewas to study further the participation of serotonin in the pathogenesis of chronic eczema. Methods. Immunohistochemical te chniqueswere used to study the expression of serotonin in the lesions of patient swith chronic eczema. Results. There was a significantly stronger expression of serotonin in the prickle cells, sweat gland cells, sebaceous gland cells, and ha ir roots of the lesions in patients with chronic eczema. There was no positive e xpression of serotonin in normal skin. Conclusions. Serotonin is probably import ant in the pathogenesis of chronic eczema. We demonstrated alterations in the ex pression of serotonin in chronic eczema lesions, which may in turn provide new i nsight into the pathogenesis of chronic eczema. Serotonin, along with cytokines, T lymphocytes, B lymphocytes, and macrophages, participates in the immune respo nse and influences the inflammatory process by means of keratinocytes.
Background. Inflammatory mediators participate in the pathogenesis an d pathop hysiology of skin disease (e.g. eczema). Although some investigators have sugges ted that serotoninmay participate in the eczematous process, there has been litt le substantial evidence. Our objectivewas to study further the participation of serotonin in the pathogenesis of chronic eczema. Methods. Immunohistochemical te chniqueswere used to study the expression of serotonin in the lesions of patient swith chronic eczema. Results. There was a significantly stronger expression of serotonin in the prickle cells, sweat gland cells, sebaceous gland cells, and ha ir roots of the lesions in patients with chronic eczema. There was no positive e xpression of serotonin in normal skin. Conclusions. Serotonin is probably import ant in the pathogenesis of chronic eczema. We demonstrated alterations in the ex pression of serotonin in chronic eczema lesions, which may in turn provide new i nsight into the pathogenesis of chronic eczema. Serotonin, along with cytokines, T lymphocytes, B lymphocytes, and macrophages, participates in the immune respo nse and influences the inflammatory process by means of keratinocytes.
