摘要
Background: Antigliadin antibodies (AGA) have been reported in patientswith p soriasis. Objectives: To determine ifAGA and other coeliac disease (CD)-associ ated antibodies correlate with clinical features and activity in patients with p soriasis. Methods: Patients with psoriasis (n = 130) were investigated for serum IgG and IgA AGA, IgA antitransglutaminase antibody and IgA antiendomysial antib ody. Disease characteristics and associated bowel and joint symptoms were determ ined. All patients were invited to undertake endoscopy with duodenal biopsy. Res ults: A significantly higher proportion of patients with elevatedCD-associated antibody levelswas currently on or had previously required systemic immunosuppr essants (methotrexate, ciclosporin or etretinate; P = 0· 04) or psoralen plus u ltraviolet A phototherapy (P = 0· 03). One case of CD was diagnosed. Conclusion s: The presence of CD-associated antibodies in psoriasis patients correlates w ith greater disease activity.
Background: Antigliadin antibodies (AGA) have been reported in patientswith p soriasis. Objectives: To determine ifAGA and other coeliac disease (CD)-associ ated antibodies correlate with clinical features and activity in patients with p soriasis. Methods: Patients with psoriasis (n = 130) were investigated for serum IgG and IgA AGA, IgA antitransglutaminase antibody and IgA antiendomysial antib ody. Disease characteristics and associated bowel and joint symptoms were determ ined. All patients were invited to undertake endoscopy with duodenal biopsy. Res ults: A significantly higher proportion of patients with elevatedCD-associated antibody levelswas currently on or had previously required systemic immunosuppr essants (methotrexate, ciclosporin or etretinate; P = 0· 04) or psoralen plus u ltraviolet A phototherapy (P = 0· 03). One case of CD was diagnosed. Conclusion s: The presence of CD-associated antibodies in psoriasis patients correlates w ith greater disease activity.
