摘要
Androgenetic alopecia (AGA) and benign prostatic hyperplasia (BPH) are both an drogen-dependent disorders, displaying in situ high levels of dihydrotestostero ne with a good therapeutic response to finasteride. Embryological development of both the hair follicle and the prostate depends on mesenchymal-epithelial inte raction, which is influenced by the expression of type 2 5α-reductase. The aim of this study was to elucidate the association between the size of the prostate gland and the prevalence and severity of AGA. A total of 46 patients age betwee n 56 and 87 years were retrospectively recruited. They fulfilling the clinical d iagnosis of BPH defined as (1) prostate volume > 30 cm3, measured by transrectal ultrasound, (2)maximal urine flow rate < 15 ml/s and mean urine flow rate < 10 ml/s, and (3) prostate serum albumin < 10 ng/ml. The control group comprised 34 patients aged between 49 and 81 years with urogenital infection, cystitis or uro lithiasis. The expression and severity of AGA were evaluated by dermatologists u sing modified Norwood/Hamilton classification. Patients with a prostate volume > 30 cm3 had a higher prevalence of AGA than patients with a smaller prostate ( < 30 cm3) (83.3%vs 61.3%; P < 0.05). The prostate size, however, did not correl ate with the severity of AGA in either group or in the whole patient group. The prevalence of AGA was not significantly different in patients with or without BP H (85.7%vs 70.6%). The prostate was slightly larger among patients with AGA th an among those without AGA (mean ±SD 42.7 ±17.4 vs 35.4 ±14.9 cm3), but this was not statistically significant. There was no significant correlation between the age of onset of AGA and the development of BPH. Our results suggest that a l arger prostate is associated with a higher prevalence of AGA. It remains to be s een if long-term use of finasteride in AGA patients will prophylactically lower the incidence of BPH.
Androgenetic alopecia (AGA) and benign prostatic hyperplasia (BPH) are both an drogen-dependent disorders, displaying in situ high levels of dihydrotestostero ne with a good therapeutic response to finasteride. Embryological development of both the hair follicle and the prostate depends on mesenchymal-epithelial inte raction, which is influenced by the expression of type 2 5α-reductase. The aim of this study was to elucidate the association between the size of the prostate gland and the prevalence and severity of AGA. A total of 46 patients age betwee n 56 and 87 years were retrospectively recruited. They fulfilling the clinical d iagnosis of BPH defined as (1) prostate volume > 30 cm3, measured by transrectal ultrasound, (2)maximal urine flow rate < 15 ml/s and mean urine flow rate < 10 ml/s, and (3) prostate serum albumin < 10 ng/ml. The control group comprised 34 patients aged between 49 and 81 years with urogenital infection, cystitis or uro lithiasis. The expression and severity of AGA were evaluated by dermatologists u sing modified Norwood/Hamilton classification. Patients with a prostate volume > 30 cm3 had a higher prevalence of AGA than patients with a smaller prostate ( < 30 cm3) (83.3%vs 61.3%; P < 0.05). The prostate size, however, did not correl ate with the severity of AGA in either group or in the whole patient group. The prevalence of AGA was not significantly different in patients with or without BP H (85.7%vs 70.6%). The prostate was slightly larger among patients with AGA th an among those without AGA (mean ±SD 42.7 ±17.4 vs 35.4 ±14.9 cm3), but this was not statistically significant. There was no significant correlation between the age of onset of AGA and the development of BPH. Our results suggest that a l arger prostate is associated with a higher prevalence of AGA. It remains to be s een if long-term use of finasteride in AGA patients will prophylactically lower the incidence of BPH.
