摘要
Background:Topical tazarotene has been shown to offer efficacy in amelioratin g multiple effects of photodamage. Objectives To evaluate the histological effec ts of tazarotene cream on photodamaged skin. Methods:In this multicentre, doubl e-blind, randomized, vehicle-controlled study, 50 patients with photodamaged f acial skin (at least mild fine wrinkling and mottled hyperpigmentation, with at least one of these being moderate) were randomized to apply tazarotene 0.1%crea m or vehicle cream to their face, once daily for 24 weeks. Results:Blinded asse ssments showed that tazarotene was less likely than vehicle to be associated wit h an increase in keratinocytic and melanocytic atypia, and more likely than vehi cle to be associated with a reduction in atypia. Between-group comparisons in d istribution of change from baseline categories of severity were in favour of taz arotene (P=0.055 for keratinocytic atypia, P= 0.034 for melanocytic atypia, and P < 0.001 for the number of granular cell layers). Compared with vehicle, tazaro tene was associatedwithanincreaseinepidermalpolarity(P=0.008)and epidermalthickn ess(P=0.012),and a tendency for stratum corneum compaction,Tazarotene was also a ssociated with widened intercellular spaces (reported as epidermal oede ma) relative to vehicle (P < 0.001). Conclusions:Treatment of photodamaged sk in with tazarotene is associated with an amelioration of keratinocytic and melan ocytic atypia, an improvement in epidermal polarity, and an increase in epiderma l thickness.
Background:Topical tazarotene has been shown to offer efficacy in amelioratin g multiple effects of photodamage. Objectives To evaluate the histological effec ts of tazarotene cream on photodamaged skin. Methods:In this multicentre, doubl e-blind, randomized, vehicle-controlled study, 50 patients with photodamaged f acial skin (at least mild fine wrinkling and mottled hyperpigmentation, with at least one of these being moderate) were randomized to apply tazarotene 0.1%crea m or vehicle cream to their face, once daily for 24 weeks. Results:Blinded asse ssments showed that tazarotene was less likely than vehicle to be associated wit h an increase in keratinocytic and melanocytic atypia, and more likely than vehi cle to be associated with a reduction in atypia. Between-group comparisons in d istribution of change from baseline categories of severity were in favour of taz arotene (P=0.055 for keratinocytic atypia, P= 0.034 for melanocytic atypia, and P < 0.001 for the number of granular cell layers). Compared with vehicle, tazaro tene was associatedwithanincreaseinepidermalpolarity(P=0.008)and epidermalthickn ess(P=0.012),and a tendency for stratum corneum compaction,Tazarotene was also a ssociated with widened intercellular spaces (reported as epidermal oede ma) relative to vehicle (P < 0.001). Conclusions:Treatment of photodamaged sk in with tazarotene is associated with an amelioration of keratinocytic and melan ocytic atypia, an improvement in epidermal polarity, and an increase in epiderma l thickness.
