摘要
In a multicentre study of the German Contact Dermatitis Research Group, sodium lauryl sulfate (SLS) 0.25%and 0.5%aq. has been added to routine allergen patc h tests to assess its properties as a convenient diagnostic indicator of individ ual susceptibility to irritation at the time of patch testing. Previous studies indicated that irritant SLS reactivity may be related to individual factors such as age and sex. As these factors are, in turn, among the important predictors o f contact allergy to many allergens, e.g. summarized in the ‘MOAHLFA index’, t he impact of the MOAHLFA factors on irritant SLS patch test reactivity, and thus a potential for confounding, was assessed in the 5971 participating patients. A s a result of 2 logistic regression analyses with an irritant reaction to 0.25% and 0.5%SLS, respectively, as outcome, male sex was identified as a relatively weak but significant risk factor (OR 1.38), while age 40 years or older was an e ven weaker risk factor (OR 1.22 and 1.15, respectively). Upon detailed analysis, no clear age gradient could, however, be identified. 1-day exposure time almos t halved the odds of an irritant SLS reaction. In conclusion, this type of SLS p atch test can be regarded as robust, indicating individual irritability relative ly independent from the individual factors analysed here.
In a multicentre study of the German Contact Dermatitis Research Group, sodium lauryl sulfate (SLS) 0.25%and 0.5%aq. has been added to routine allergen patc h tests to assess its properties as a convenient diagnostic indicator of individ ual susceptibility to irritation at the time of patch testing. Previous studies indicated that irritant SLS reactivity may be related to individual factors such as age and sex. As these factors are, in turn, among the important predictors o f contact allergy to many allergens, e.g. summarized in the ‘MOAHLFA index’, t he impact of the MOAHLFA factors on irritant SLS patch test reactivity, and thus a potential for confounding, was assessed in the 5971 participating patients. A s a result of 2 logistic regression analyses with an irritant reaction to 0.25% and 0.5%SLS, respectively, as outcome, male sex was identified as a relatively weak but significant risk factor (OR 1.38), while age 40 years or older was an e ven weaker risk factor (OR 1.22 and 1.15, respectively). Upon detailed analysis, no clear age gradient could, however, be identified. 1-day exposure time almos t halved the odds of an irritant SLS reaction. In conclusion, this type of SLS p atch test can be regarded as robust, indicating individual irritability relative ly independent from the individual factors analysed here.
