摘要
Hyperandrogenism with hyperandrogenemia should be considered in those with sev ere acne of sudden onset or conspicuous male-pattern baldness with hairline rec ession, although the majority of female patients with acne or androgenetic alope cia possess no endocrine diorder. Herein we describe on the contrary 2 young wom en with primary amenorrhea displaying prominent hyperandrogenemia but subtle cut aneous manifestation. The first one presenting vertical alopecia had an elevated level of serum dehydroepiandrosterone sulfate (>800 μg/dl)and was suspected to be a case of late-onset, non-classical adrenal hyperplasia. The second case w ith mild acne had a soaring serum level of total testosterone >9,000 ng/dl deriv ed from an androgen-secreting adrenal adenoma overexpressing steroidogenic acut e regulatory protein, P450 side-chain cleavage enzyme and aromatase. A careful patient history and a complete physical examination are mandatory in each indivi dual female case with acne or alopecia. The possibility of adrenal tumor should be explored in patients with escalated circulating testosterone.
Hyperandrogenism with hyperandrogenemia should be considered in those with sev ere acne of sudden onset or conspicuous male-pattern baldness with hairline rec ession, although the majority of female patients with acne or androgenetic alope cia possess no endocrine diorder. Herein we describe on the contrary 2 young wom en with primary amenorrhea displaying prominent hyperandrogenemia but subtle cut aneous manifestation. The first one presenting vertical alopecia had an elevated level of serum dehydroepiandrosterone sulfate (>800 μg/dl)and was suspected to be a case of late-onset, non-classical adrenal hyperplasia. The second case w ith mild acne had a soaring serum level of total testosterone >9,000 ng/dl deriv ed from an androgen-secreting adrenal adenoma overexpressing steroidogenic acut e regulatory protein, P450 side-chain cleavage enzyme and aromatase. A careful patient history and a complete physical examination are mandatory in each indivi dual female case with acne or alopecia. The possibility of adrenal tumor should be explored in patients with escalated circulating testosterone.
