摘要
We investigated the expression of CD10 by an immunohistochemical method in 51 basal cell carcinomas (BCCs), eight pilomatricomas, five trichoblastomas, two tr ichofolliculomas, three sebaceomas, five sebaceous carcinomas, ten syringomas, t wo spiradenomas, ten poromas, four porocarcinomas, one eccrine duct carcinoma (n ot otherwise specified, NOS), six mixed tumors of apocrine origin, and nine squa mous cell carcinomas (SCCs). We detected strong expression of CD10 in tumor cell s of BCC(86%),and found that the smaller the number of positive tumor cells, th e larger the number of positive stromal cells, in particular in sclerosing BCCs. Spearman’s rank correlation test revealed a significant negative correlation i n BCCs between the expression of CD10 in tumor cells and that in stromal cells (P=0.001). In all pilomatricomas (100%) and in four trichoblast omas (80%), strong expression was also detected in tumor cells. There was no de tectable expression in trichofolliculomas. One sebaceoma (33%) and two sebaceou s carcinomas (40%)expressed CD10 in a similar fashion to BCCs. All tumors of ec crine gland origin, including syringoma, spiradenoma, poroma, porocarcinoma, and eccrine duct carcinoma (NOS), did not express CD10. Five mixed tumors (83%) we re immunopositive. In SCC, CD10 was overexpressed only in the stromal cells. The se findings support the hypothesis that BCC is derived from the folliculo-sebac eous apocrine unit, especially having the same origin as trichoblastoma and pilo matricoma. CD10 might be an indicator of tumor invasiveness if it is expressed i n stromal cells, while it might be a marker of follicular differentiation if it is expressed in the actual tumor cells of cutaneous epithelial neoplasms.
We investigated the expression of CD10 by an immunohistochemical method in 51 basal cell carcinomas (BCCs), eight pilomatricomas, five trichoblastomas, two tr ichofolliculomas, three sebaceomas, five sebaceous carcinomas, ten syringomas, t wo spiradenomas, ten poromas, four porocarcinomas, one eccrine duct carcinoma (n ot otherwise specified, NOS), six mixed tumors of apocrine origin, and nine squa mous cell carcinomas (SCCs). We detected strong expression of CD10 in tumor cell s of BCC(86%),and found that the smaller the number of positive tumor cells, th e larger the number of positive stromal cells, in particular in sclerosing BCCs. Spearman's rank correlation test revealed a significant negative correlation i n BCCs between the expression of CD10 in tumor cells and that in stromal cells (P=0.001). In all pilomatricomas (100%) and in four trichoblast omas (80%), strong expression was also detected in tumor cells. There was no de tectable expression in trichofolliculomas. One sebaceoma (33%) and two sebaceou s carcinomas (40%)expressed CD10 in a similar fashion to BCCs. All tumors of ec crine gland origin, including syringoma, spiradenoma, poroma, porocarcinoma, and eccrine duct carcinoma (NOS), did not express CD10. Five mixed tumors (83%) we re immunopositive. In SCC, CD10 was overexpressed only in the stromal cells. The se findings support the hypothesis that BCC is derived from the folliculo-sebac eous apocrine unit, especially having the same origin as trichoblastoma and pilo matricoma. CD10 might be an indicator of tumor invasiveness if it is expressed i n stromal cells, while it might be a marker of follicular differentiation if it is expressed in the actual tumor cells of cutaneous epithelial neoplasms.
