摘要
Childhood vitiligo is a common disorder of pigmentation in India. Considering the lack of uniformly effective and safe treatment modalities for children with vitiligo, search for newer therapeutic agents continues. This study was designed to evaluate the role of topical tacrolimus in the treatment of childhood vitili go. Twenty-five children with vitiligo were treated with topical 0.03%tacrolim us ointment applied twice daily for 12 weeks. Response was noted as marked to co mplete ( > 75%repigmentation), moderate (50-75%repigmentation) and mild ( < 5 0%repigmentation). Twenty-two children (9 boys and 13 girls) of mean age 7.2 ±1.4 years completed the study. Twelve (54.5%) children had vitiligo vulgaris, nine (40.9%) had focal vitiligo and one (4.5%) had segmental vitiligo. The me an duration of disease was 8 ±3 months. Nineteen (86.4%) children showed some repigmentation at the end of 3 months and other three had no response. Of these 19 children, repigmentation was markedtocompletein11(57.9%),moderateinfive(26.3 %)and mild in three (15.7%) children. Side effects were minimal, such as the p ruritus and burning noted in only three patients. Topical tacrolimus is an effec tive and well-tolerated treatment modality in Asian children with vitiligo.
Childhood vitiligo is a common disorder of pigmentation in India. Considering the lack of uniformly effective and safe treatment modalities for children with vitiligo, search for newer therapeutic agents continues. This study was designed to evaluate the role of topical tacrolimus in the treatment of childhood vitili go. Twenty-five children with vitiligo were treated with topical 0.03%tacrolim us ointment applied twice daily for 12 weeks. Response was noted as marked to co mplete ( > 75%repigmentation), moderate (50-75%repigmentation) and mild ( < 5 0%repigmentation). Twenty-two children (9 boys and 13 girls) of mean age 7.2 ±1.4 years completed the study. Twelve (54.5%) children had vitiligo vulgaris, nine (40.9%) had focal vitiligo and one (4.5%) had segmental vitiligo. The me an duration of disease was 8 ±3 months. Nineteen (86.4%) children showed some repigmentation at the end of 3 months and other three had no response. Of these 19 children, repigmentation was markedtocompletein11(57.9%),moderateinfive(26.3 %)and mild in three (15.7%) children. Side effects were minimal, such as the p ruritus and burning noted in only three patients. Topical tacrolimus is an effec tive and well-tolerated treatment modality in Asian children with vitiligo.
