摘要
We describe two cases of a malignant cutaneous neoplasm with combined phenotypical features of high- grade basal cell carcinoma and malignant melanoma. Some tumor cells showed a keratinocytic phenotype (cytokeratins, p63) and others a melanocytic phenotype (HMB- 45, MART- 1, Melan- A, S100- protein). We favor the hypothesis of a tumor with bidirectional keratinocytic and melanocytic differentiation, an exceptionally rare event.
We describe two cases of a malignant cutaneous neoplasm with combined phenotypical features of high- grade basal cell carcinoma and malignant melanoma. Some tumor cells showed a keratinocytic phenotype (cytokeratins, p63) and others a melanocytic phenotype (HMB- 45, MART- 1, Melan- A, S100- protein). We favor the hypothesis of a tumor with bidirectional keratinocytic and melanocytic differentiation, an exceptionally rare event.
