摘要
Background: Dead Sea (DS) salt solution soaks are used in combination with narrowband ultraviolet B (NB- UVB) to treat psoriasis in many centres, particularly in continental Europe. No previously published controlled study has assessed DS salt + NB- UVB balneophototherapy. Objectives: To compareDS salt balneophototherapy with NB- UVB monotherapy for chronic plaque psoriasis. Methods: Sixty patients with chronic plaque psoriasis participated in this paired, controlled study, with pretreatment DS salt soaks randomly allocated to each participant’ s right or left study limb. Psoriasis severity was assessed with a Scaling, Erythema and Induration score by a blinded observer. Assessments were weekly during the therapy course, and thereafter 8- weekly until relapse or for up to 1 year after clearance. Results: The mean area under the psoriasis severity- time curves during treatment was not detectably lower with DS salt balneophototherapy than with NB- UVB monotherapy (P=0.099). The psoriasis severity score fell slightly more from beginning to end of courses with DS salt balneophototherapy than with NB- UVB monotherapy (P=0.019). There was no detectable difference in times to relapse. Conclusions: In this population the addition of pretreatment DS salt soaks to NB- UVB did not result in a clinically important improvement in clearance of psoriasis.
Background: Dead Sea (DS) salt solution soaks are used in combination with narrowband ultraviolet B (NB- UVB) to treat psoriasis in many centres, particularly in continental Europe. No previously published controlled study has assessed DS salt + NB- UVB balneophototherapy. Objectives: To compareDS salt balneophototherapy with NB- UVB monotherapy for chronic plaque psoriasis. Methods: Sixty patients with chronic plaque psoriasis participated in this paired, controlled study, with pretreatment DS salt soaks randomly allocated to each participant' s right or left study limb. Psoriasis severity was assessed with a Scaling, Erythema and Induration score by a blinded observer. Assessments were weekly during the therapy course, and thereafter 8- weekly until relapse or for up to 1 year after clearance. Results: The mean area under the psoriasis severity- time curves during treatment was not detectably lower with DS salt balneophototherapy than with NB- UVB monotherapy (P=0.099). The psoriasis severity score fell slightly more from beginning to end of courses with DS salt balneophototherapy than with NB- UVB monotherapy (P=0.019). There was no detectable difference in times to relapse. Conclusions: In this population the addition of pretreatment DS salt soaks to NB- UVB did not result in a clinically important improvement in clearance of psoriasis.
