摘要
Introduction.Drug hypersensitivity syndrome is a severe life-threatening drug reaction.An association between this syndrome and HHV6 reactivation has been hypothesized.Casereport.A 45 year-old women was treated with sulfasalazine for polyarthralgia.One month after beginning the treatment,she developed a drug hypersensitivity syndrome with severe acute hepatic failure.HHV6 serology and serum PCR revealed a primary HHV6 infection.Discussion.We report the second case of drug hypersensitivity syndrome associated with a primary HHV6 infection.An immunological disorder may explain such an association by increasing viral replication.Detection and titration of anti-HHV6 antibodies in each case of drug hypersensitivity syndrome should help to confirm this association and possibly modify treatment strategy.
Introduction.Drug hypersensitivity syndrome is a severe life-threatening drug reaction.An association between this syndrome and HHV6 reactivation has been hypothesized.Casereport.A 45 year-old women was treated with sulfasalazine for polyarthralgia.One month after beginning the treatment,she developed a drug hypersensitivity syndrome with severe acute hepatic failure.HHV6 serology and serum PCR revealed a primary HHV6 infection.Discussion.We report the second case of drug hypersensitivity syndrome associated with a primary HHV6 infection.An immunological disorder may explain such an association by increasing viral replication.Detection and titration of anti-HHV6 antibodies in each case of drug hypersensitivity syndrome should help to confirm this association and possibly modify treatment strategy.
