摘要
研究背景和目的:研究显示,血清瘦素和胰岛素样生长因子1(IGF-1)水平可能参与动脉粥样硬化的发病机制。因此,本研究以1型糖尿病的儿童及青少年患者为对象,检测颈动脉内中膜厚度(IMT)及颈总动脉(CCA)功能与此两种血清成分的相关性。材料和方法: 测定45例糖尿病患儿(女性组23例,男性组22例),检测其血清内瘦素和IGF-1浓度。对比男女患儿的年龄、糖尿病病程和主要心血管发病风险因素。
Background and aim: Leptin and insulin-like growth factor - 1 (IGF - 1) have been suggested to be involved in the pathogenesis of atherosclerosis. The aim of this study was to evaluate the relationship between serum leptin, IGF - 1 and intima-media thickness (IMT) and functions of common carotid artery (CCA) in children and adolescent patients with type 1 diabetes. Material and methods: Serum leptin and IGF - 1 levels were measured in 45 diabetic patients (23 girls and 22 boys). Age, diabetes duration as well as major cardiovascular risk factors, including an-thropometric and metabolic parameters, were matched between girls and boys. The relation of serum leptin and IGF - 1 levels to CCA structure and functions were measured by ultrasonography as IMT, cross-sectional compliance (CSC), cross-sectional distensibility (CSD), dias-tolicwall stress (DWS) and incremental elastic modulus (IEM) . Results: Serum leprin levels of diabetic girls were higher than those in the boys (21. 8 ± 14. 5μg/l vs 8. 9 ± 10. 6 μg/l, p = 0.002). However, the difference for serum IGF - 1 levels was not significant between diabetic girls and boys (240. 7 ± 96. 8 ng/ml vs 234. 7 ± 93. 2 ng/ml; p > 0. 05) . In all subjects, leptin levels were correlated with CSC (p = 0.04), CSD (p = 0.04) and IEM (p = 0. 01), and IGF - I levels were only correlated with CSC (p = 0. 01). Leptin did not show any correlation with ultrasonographic measurements in both girls and boys separately. IGF -1 was correlated with CSC (p = 0.001), CSD (p = 0.002) and IEM (p < 0.001) in boys but not in girls. In a multivariate regression model, IGF - 1 emerged as independent correlates for mean CSD and IEM in boys but not in girls. Conclusion: Serum leptin and IGF - 1 levels in children and adolescent patients with type 1 diabetes are associated with functions of common carotid artery, and the association of IGF - 1 levels is influenced by sex.
