摘要
目的:通过高分辨率CT(HRCT)图像分析囊性纤维病(CF)患儿与正常儿童间是否存在气道结构差异。试验设计:获取肺完全膨胀及控制通气的状态的四维解剖水平的HRCT图像,研究对象包括34例CF患儿(年龄2.4±1.4岁)及20名正常对照儿童(年龄1.8±1.4 岁)。测量所有清晰可见的圆形通气管道的短轴直径以获取气道壁厚度(AWT),气道管腔内径(ALD)以及气道直径(VD)。结果:在CF组(x±s),AWT为0.58±0.13 mm,ALD为1.31±0.56 mm,VD为1.62±0.58 mm。在对照组:AWT为0.49±0.13 mm,ALD为1.07±0.42 mm,VD为1.86±0.64 mm。
Objectives To determine whether the airway structure of infants and young children with cystic fibrosis (CF) differs from that of normal children by using high-resolution computed tomography (HRCT) imaging. Study design Full-inflation, controlled ventilation HRCT images of the lungs were obtained at four anatomic levels in 34 infants with CF (age, 2. 4 ±1.4 years) and 20 control infants (age, 1. 8± 1. 4 years). Short axis diameters of all clearly identifiable, round airway/vessel pairswere measured to obtain airway wall thickness (AWT), airway lumen diameter (ALD), and vessel diameter (VD). Results In infants with CF, mean AWT ( ±SD) was 0. 58±0. 13 mm, ALD was 1. 31±0. 56 mm, and VD was 1. 62±0. 58 mm. In control infants, mean AWT was 0. 49±0. 13 mm, ALD was 1.07±0.42 mm, and VD was 1.86±0.64 mm. Mean AWT and ALD were greater in children with CF than in normal subjects (P <. 001). ALD: VD ratios increased with age in patients with CF compared with control subjects (P = . 026). Conclusions The airways of infants and young children with CF have thicker walls and are more dilated than those of normal infants.
