摘要
Background: Iron deficiency causes abnormal dopaminergic neurotransmission and may contribute to the physiopathology of attention-deficit/hyperactivity disorder (ADHD). Objective: To evaluate iron deficiency in children with ADHD vs iron deficiency in an age-and sex-matched control group. Design: Controlled group comparison study. Setting: Child and Adolescent Psychopathology Department in European Pediatric Hospital, Paris, France Patients: Fifty-three children with ADHD aged 4 to 14 years (mean ±SD, 9.2 ±2.2 years) and 27 controls (mean ±SD, 9.5 ±2.8 years). Main Outcome Measures: Serumferritin levels evaluating iron stores and Conners’Parent Rating Scale scores measuring severity of ADHD symptoms have been obtained. Results: The mean serum ferritin levels were lower in the children with ADHD (mean ±SD, 23 ±13 ng/mL) than in the controls (mean ±SD, 44 ±22 ng/mL; P < .001). Serum ferritin levels were abnormal (< 30 ng/mL) in 84%of children with ADHD and 18%of controls (P < .001). In addition, low serum ferritin levels were correlated with more severe general ADHD symptoms measured with Conners’Parent Rating Scale (Pearson correlation coefficient, r = -0.34; P < .02) and greater cognitive deficits (r = -0.38; P < .01). Conclusions: These results suggest that low iron stores contribute to ADHD and that ADHD childrenmay benefit from iron supplementation.
Background: Iron deficiency causes abnormal dopaminergic neurotransmission and may contribute to the physiopathology of attention-deficit/hyperactivity disorder (ADHD). Objective: To evaluate iron deficiency in children with ADHD vs iron deficiency in an age-and sex-matched control group. Design: Controlled group comparison study. Setting: Child and Adolescent Psychopathology Department in European Pediatric Hospital, Paris, France Patients: Fifty-three children with ADHD aged 4 to 14 years (mean ±SD, 9.2 ±2.2 years) and 27 controls (mean ±SD, 9.5 ±2.8 years). Main Outcome Measures: Serumferritin levels evaluating iron stores and Conners’Parent Rating Scale scores measuring severity of ADHD symptoms have been obtained. Results: The mean serum ferritin levels were lower in the children with ADHD (mean ±SD, 23 ±13 ng/mL) than in the controls (mean ±SD, 44 ±22 ng/mL; P < .001). Serum ferritin levels were abnormal (< 30 ng/mL) in 84%of children with ADHD and 18%of controls (P < .001). In addition, low serum ferritin levels were correlated with more severe general ADHD symptoms measured with Conners’Parent Rating Scale (Pearson correlation coefficient, r = -0.34; P < .02) and greater cognitive deficits (r = -0.38; P < .01). Conclusions: These results suggest that low iron stores contribute to ADHD and that ADHD childrenmay benefit from iron supplementation.
