摘要
Objective: To evaluate the effect of zinc supplementation on mental and psych omotor scores in children aged 12 to 18 months. Study design: In this double- b lind, randomized, placebo- controlled trial, children aged 6 to 30 months recei ved daily elemental zinc (10 mg for infants and 20 mg for others) or placebo for 4 months. Bayley Scales of Infant Development II were used for development asse ssment in the 12- to 18- month subgroup at enrollment and the end of the study . Results: At the end of the study, the adjusted mean mental (P = .36) and psych omotor (P = .28) index scores were similar in the intervention and control group s. In a multivariate model, the baseline mental development index score was posi tively associated with the mother’s schooling, the child’s height for age, p acked cell volumes, hospital birth, and attendance at a day care center, and was negatively associated with the child’s age. Breastfeeding, the child’s weig ht for height, and packed cell volumes were positively associated with the basel ine psychomotor index score. Conclusion: Zinc supplementation did not affect the mental or psychomotor development index scores in a setting in which zinc defic iency is common.
Objective: To evaluate the effect of zinc supplementation on mental and psych omotor scores in children aged 12 to 18 months. Study design: In this double- b lind, randomized, placebo- controlled trial, children aged 6 to 30 months recei ved daily elemental zinc (10 mg for infants and 20 mg for others) or placebo for 4 months. Bayley Scales of Infant Development II were used for development asse ssment in the 12- to 18- month subgroup at enrollment and the end of the study . Results: At the end of the study, the adjusted mean mental (P = .36) and psych omotor (P = .28) index scores were similar in the intervention and control group s. In a multivariate model, the baseline mental development index score was posi tively associated with the mother's schooling, the child's height for age, p acked cell volumes, hospital birth, and attendance at a day care center, and was negatively associated with the child's age. Breastfeeding, the child's weig ht for height, and packed cell volumes were positively associated with the basel ine psychomotor index score. Conclusion: Zinc supplementation did not affect the mental or psychomotor development index scores in a setting in which zinc defic iency is common.
