摘要
We describe cholestasis as a result of bile duct abnormalities in 8 children with portal vein obstruction. In a clinical, biochemical and radiological invest igation of 121 children with cavernous transformation of the portal vein seen be tween 1986 and 2000, 8 presented with jaundice, pruritus, and/or raised serum am inotransferases and/or gamma glutamyl transpeptidase (gamma GT) activities. Each displayed dilation and narrowing of intraand/ or extrahepatic bile ducts. Surgi cal decompression of the portal system (portal- systemic or Rex anastomosis) re sulted in the regression of the signs of cholestasis in all children. We conclud e that children with portal vein obstruction may exhibit clinically significant cholestasis as a result of external compression of the bile duct by the cavernom a.
We describe cholestasis as a result of bile duct abnormalities in 8 children with portal vein obstruction. In a clinical, biochemical and radiological invest igation of 121 children with cavernous transformation of the portal vein seen be tween 1986 and 2000, 8 presented with jaundice, pruritus, and/or raised serum am inotransferases and/or gamma glutamyl transpeptidase (gamma GT) activities. Each displayed dilation and narrowing of intraand/ or extrahepatic bile ducts. Surgi cal decompression of the portal system (portal- systemic or Rex anastomosis) re sulted in the regression of the signs of cholestasis in all children. We conclud e that children with portal vein obstruction may exhibit clinically significant cholestasis as a result of external compression of the bile duct by the cavernom a.
