罗比卡因用于小儿骶管阻滞麻醉

Efficacy of caudal injection ropivacaine in pediatric patients

目的 比较0.25％罗比卡因和0.25％布比卡因在小儿骶管阻滞中麻醉效果和作用时间,探讨其在小儿麻醉的可行性。方法 60例2～6岁腹股沟斜疝择期手术的幼儿,随机分为R组和B组,每组30例。所有患儿进手术室后均行骶管穿刺,R组局麻药采用0.25％罗比卡因1mL·kg^(-1),B组用0.25％布比卡因1mL·kg^(-1)。结果 术中两组间心率、血压无显著性差异,但心率较基础值有轻微增加。R组和B组镇痛持续时间分别为352±52min和352±72min(P>0.05),但从术后2h开始,运动阻滞程度R组明显小于B组(P<0.05),术后4h在B组仍有轻度运动阻滞。结论 在小儿骶管阻滞,0.25％罗比卡因和0.25％布比卡因1mL·kg^(-1)均有良好的镇痛效果和较长的镇痛时间,但0.25％罗比卡因更适用于小儿骶管阻滞。

Objective We compared analgesic efficacy and duration of analgesia by ropivacaine 0. 25% , with bupivacaine 0. 25% , for caudal anesthesia in children. Methods Sixty 2-6 years - old children undergoing inguinal hernia repair were randomly divided into two groups: ropivacaine group (group r, n=30) and bupivacaine group (group B, n = 30) . They were administered as a caudal injection at a dose of ImL·kg-1 of ropivacaine 0. 25% in group R, or at a dose 1mL·kg-1 of bupivacaine 0. 25% in group B. Results There were no differences in heart rate and arterial pressure between the two groups. Duration of caudal analgesia of group R and group B was 352±52min and 352±72min respectively (P> 0. 05). But the group Rshowed signicantly less motor block after 2h postoperatively than the group B( P <0. 05), and the group B showed still less motor block after 4h post-operatively. Conclusion The caudal anesthesia with bupivacaine 0. 25% in pediatric patients provides pain relief similar to bupicavaine 0. 25%. The less motor block of bupivacaine 0. 25% is available to the caudal anesthesia in children.