摘要
Purpose To analyze the baseline find ings predictive of the size and type of the late exudative age-related macular de-generation(AMD)lesions.Design Observational case se-ries.Methods Retrospective study.Setting:University clinic referral practice.Study pop ulation:The records of167consecutive patients initially diagnosed with recent choroidal neovascularization(CNV)related to AMD were analyzed 4.8to 9.2(mean 6.8)years after baseline.Of 121patients still living,74attend ed the reexamination.After exclusions,data from 61patie nts were analyzed.OBSERVATION PROCEDURES:From the fu ndus pho-tographs and fluorescein angiograp hic images taken at baseline and at follow-up the size an d components of AMD lesion were measured.The presence o f hemorrhage,pig-ment epithelial detachment (PED),classic CNV,laser treatment,and involvement of the fe llow eye were recorded at baseline.Main outcome measures:Lesion size,increase in lesion size,persistent exudativ e process,subretinal fi-brosis,and chorioretinal anastomo sis at the follow-up ex-amination.Results Large lesion(P<.001)and CNV(P=.003)sizes,and the presence of occult,no classic CNV(P=.013)at baseline predict a large lesion at fol-low-up.Other factors predicting a l arge lesion were sub-foveal(P=.019)and bilateral lesions(P=.017)and the presence of hemorrhage(P=.012)at baseline.A large(P=.040)and bilateral lesion(P=.040)and hemorrhage(P=.011)at baseline were correlated with subretinal fibrosis at follow-up.Occult lesions(P=.002)at baseline were correlated with chorioretinal anastomosis at follow-up.Conclusion The type and s ize of the late AMD lesion can partly be predicted from b aseline characteristics.
Purpose To analyze the baseline find ings predictive of the size and type of the late exudative age-related macular de-generation(AMD)lesions.Design Observational case se-ries.Methods Retrospective study.Setting:University clinic referral practice.Study pop ulation:The records of167consecutive patients initially diagnosed with recent choroidal neovascularization(CNV)related to AMD were analyzed 4.8to 9.2(mean 6.8)years after baseline.Of 121patients still living,74attend ed the reexamination.After exclusions,data from 61patie nts were analyzed.OBSERVATION PROCEDURES:From the fu ndus pho-tographs and fluorescein angiograp hic images taken at baseline and at follow-up the size an d components of AMD lesion were measured.The presence o f hemorrhage,pig-ment epithelial detachment (PED),classic CNV,laser treatment,and involvement of the fe llow eye were recorded at baseline.Main outcome measures:Lesion size,increase in lesion size,persistent exudativ e process,subretinal fi-brosis,and chorioretinal anastomo sis at the follow-up ex-amination.Results Large lesion(P<.001)and CNV(P=.003)sizes,and the presence of occult,no classic CNV(P=.013)at baseline predict a large lesion at fol-low-up.Other factors predicting a l arge lesion were sub-foveal(P=.019)and bilateral lesions(P=.017)and the presence of hemorrhage(P=.012)at baseline.A large(P=.040)and bilateral lesion(P=.040)and hemorrhage(P=.011)at baseline were correlated with subretinal fibrosis at follow-up.Occult lesions(P=.002)at baseline were correlated with chorioretinal anastomosis at follow-up.Conclusion The type and s ize of the late AMD lesion can partly be predicted from b aseline characteristics.
出处
《世界核心医学期刊文摘（眼科学分册）》
2005年第1期12-13,共2页
Digest of the World Core Medical Journals:Ophthalmology
