妊娠期服用拉坦前列素对孕妇及胎儿的影响

Latanoprost exposure in pregnancy

Purpose To observe pregnancies exposed to latanoprost,a prostaglandin analog administered in the treatment of glaucoma.Its prescription is limited in pregnancy,because reproduction studies in animals rep ort a high incidence of abortion and human investigations a re not adequate.As a consequence it is classified as category C drug accord-ing to the United States Food and Drug Administrations use-in-pregnancy ratings.Design O bservational study.Methods We collected data,referred to our Teratology In-formation Service,relative to lata noprost exposure in pregnancy.We followed by phone inte rviews women treated with latanoprost during the first tr imester,and we evaluated whether there had been any adverse effects on the fetus.Results Eleven cases of latanoprost exposure in pregnancy were referred to our Teratology Info rmation Service.One case was lost to follow-up,and one case was complicated by miscarriage.Nine cases had a comp lete follow-up without congenital anomalies.Conclusions Our series is too small to perform statistical signif icance;however,we found no evidence of adverse effects of latanoprost on pregnancy or neonatal outcomes.