摘要
Purpose.To assess whether thyroid d isease is indepen-dently associated with open-angle g laucoma (OAG),using history of thyroid disease and curre nt thyroxine use.Methods.The Blue Mountains Eye Stud y examined 3654persons,aged 49-97years.Intervie wers collected self-reported history of diagnosis and treatment for thyroid disease.Eye examinations included applanation tonome-try,stereoscopic optic disc photography and automated perimetry.OAG was diagnosed from th e presence of matching typical glaucomatous field changes and optic disc cupping,independent of intraocula r pressure.Associations between thyroid disease(history and treatment )and OAG were assessed in a multivariate model.Results.Of 324participants(8.9%)reporting history of thyroid disease,147(4.0%)were currently using thyroxine.Although we could not accurately categorize the thyroid disorder for all cases,current use of thyroxine sugg ests a prior hypothyroid state.All thyroid dise ase subgroups affected women more frequently than men,P=0.001.OAG was diagnosed in 108subjects(3.0%)and was more frequent in those reporting past thyroid dise ase(4.6vs2.8%).This relationship was not statistic ally significant after ad-justing for potential confounders,multivariate odds ratio(OR)1.6;95%confidence interval(95%CI 0.9-2.9).OAG was significantly more frequen t,however,in subjects reporting current thyroxine use(6.8vs2.8%),multivariate OR 2.1;95%CI 1.0-4.4,or history of thyroid surgery(6.5vs2.8%),multivariate OR 2.5;95%CI 1.0-6.2.Conclusions.This population-based study suggests that thyroid disease,indicated by current thyroxine use or past thyroid surgery,could be indepen-dently related to OAG.
Purpose.To assess whether thyroid d isease is indepen-dently associated with open-angle g laucoma (OAG),using history of thyroid disease and curre nt thyroxine use.Methods.The Blue Mountains Eye Stud y examined 3654persons,aged 49-97years.Intervie wers collected self-reported history of diagnosis and treatment for thyroid disease.Eye examinations included applanation tonome-try,stereoscopic optic disc photography and automated perimetry.OAG was diagnosed from th e presence of matching typical glaucomatous field changes and optic disc cupping,independent of intraocula r pressure.Associations between thyroid disease(history and treatment )and OAG were assessed in a multivariate model.Results.Of 324participants(8.9%)reporting history of thyroid disease,147(4.0%)were currently using thyroxine.Although we could not accurately categorize the thyroid disorder for all cases,current use of thyroxine sugg ests a prior hypothyroid state.All thyroid dise ase subgroups affected women more frequently than men,P=0.001.OAG was diagnosed in 108subjects(3.0%)and was more frequent in those reporting past thyroid dise ase(4.6vs2.8%).This relationship was not statistic ally significant after ad-justing for potential confounders,multivariate odds ratio(OR)1.6;95%confidence interval(95%CI 0.9-2.9).OAG was significantly more frequen t,however,in subjects reporting current thyroxine use(6.8vs2.8%),multivariate OR 2.1;95%CI 1.0-4.4,or history of thyroid surgery(6.5vs2.8%),multivariate OR 2.5;95%CI 1.0-6.2.Conclusions.This population-based study suggests that thyroid disease,indicated by current thyroxine use or past thyroid surgery,could be indepen-dently related to OAG.
出处
《世界核心医学期刊文摘（眼科学分册）》
2005年第1期35-36,共2页
Digest of the World Core Medical Journals:Ophthalmology
