摘要
PURPOSE. To demonstrate that corneal light-backscatter can be measured object ively during corneal swelling by optical coherence tomography (OCT). METHODS. On e eye (randomly selected) of 20 non-contact-lens wearers (10 men and 10 women; mean age, 35.6 ±9.6 years) was patched during 3 hours of soft contact lens (SC L) wear. The contralateral eye acted as the control. Central corneal images were captured before and after SCL wear at 20-minute intervals over 100 minutes usi ng optical coherence tomography (OCT) to obtain corneal thickness and light-bac kscatter profiles. OCT backscattered light of the epithelial layer (decided by t he thickness measurements) and 10 equally divided layers of the remaining cornea were analyzed with a custom soft ware program. Two baseline measurements were t aken at different visits before lens wear to test the repeatability of light-ba ckscatter measurements. RESULTS. From two baseline measurements, repeated measur ements showed good repeatability of normalized backscatter results. Immediately after contact lens removal, total central corneal thickness increased significan tly by 13.8%±2.3%(mean ±SD) compared with baseline (P=0.0001, paired t-test ) and then decreased during the deswelling course. Corneal backscattered light c hanged significantly (repeated-measures ANOVA Re-ANOVA: F(50,950)=2.22, P=0. 0001) after lens wear, and a significant increase in backscatter was found in th e epithelial layer (36.4%) and the most posterior corneal layer (35.6%) immedi ately after lens removal (post hoc test, P=0.005). There was a strong correlatio n (r=0.9375, P< 0.05) between the change in backscatter and corneal swelling dur ing the deswelling period. The backscatter recovery rate was approximately the s ame for both epithelial and posterior layers after lens removal. CONCLUSIONS. Li ght- backscattering analysis with OCT seems to be a promising and repeatable method of objectively measuring corneal backscatter. This study has demonstrated that corneal backscattered light increased in the anterior and posterior layers of th e cornea during corneal swelling induced by contact lens wear and eye closure.
PURPOSE. To demonstrate that corneal light-backscatter can be measured object ively during corneal swelling by optical coherence tomography (OCT). METHODS. On e eye (randomly selected) of 20 non-contact-lens wearers (10 men and 10 women; mean age, 35.6 ±9.6 years) was patched during 3 hours of soft contact lens (SC L) wear. The contralateral eye acted as the control. Central corneal images were captured before and after SCL wear at 20-minute intervals over 100 minutes usi ng optical coherence tomography (OCT) to obtain corneal thickness and light-bac kscatter profiles. OCT backscattered light of the epithelial layer (decided by t he thickness measurements) and 10 equally divided layers of the remaining cornea were analyzed with a custom soft ware program. Two baseline measurements were t aken at different visits before lens wear to test the repeatability of light-ba ckscatter measurements. RESULTS. From two baseline measurements, repeated measur ements showed good repeatability of normalized backscatter results. Immediately after contact lens removal, total central corneal thickness increased significan tly by 13.8%±2.3%(mean ±SD) compared with baseline (P=0.0001, paired t-test ) and then decreased during the deswelling course. Corneal backscattered light c hanged significantly (repeated-measures ANOVA Re-ANOVA: F(50,950)=2.22, P=0. 0001) after lens wear, and a significant increase in backscatter was found in th e epithelial layer (36.4%) and the most posterior corneal layer (35.6%) immedi ately after lens removal (post hoc test, P=0.005). There was a strong correlatio n (r=0.9375, P< 0.05) between the change in backscatter and corneal swelling dur ing the deswelling period. The backscatter recovery rate was approximately the s ame for both epithelial and posterior layers after lens removal. CONCLUSIONS. Li ght- backscattering analysis with OCT seems to be a promising and repeatable method of objectively measuring corneal backscatter. This study has demonstrated that corneal backscattered light increased in the anterior and posterior layers of th e cornea during corneal swelling induced by contact lens wear and eye closure.
出处
《世界核心医学期刊文摘（眼科学分册）》
2005年第2期34-35,共2页
Digest of the World Core Medical Journals:Ophthalmology
