摘要
Purpose To measure the axial movement of an accommodating intraocular lens (IO L) induced by ciliary muscle contraction after application of pilocarpine. Desig n Randomized, controlled, patient and examiner masked trial with intrapatient co mparison. Participants and controls One hundred ten eyes of 55 patients with age -related bilateral cataract. Methods This study was divided into 3 parts. In th e first, the accommodating IOL (1CU) was compared with a 3-piece open-loop acr ylic IOL that served as the control. In the second, to assess the effect of caps ule fibrosis on the potential accommodating performance of the accommodating IOL , extensive polishing of the anterior capsule with a slit cannula was compared w ith standard surgery. In the third, the effect of a posterior capsulorhexis was compared with that of standard surgery. Anterior chamber depth (ACD) was assesse d with partial coherence interferometry, measured before and after topical appli cation of pilocarpine 2%, and near visual acuity (VA) was evaluated 3 months af ter surgery. Main outcome measure Pilocarpine-induced change in ACD. Results Th e accommodating IOL showed a forward movement under pilocarpine with a median am plitude of movement of -314 μm (95%confidence interval CI: -148 to -592), compared with the backward movement of 63 μm (95%CI: 161 to -41) for the ope n-loop control IOL (P=0.001). Capsule polishing and a posterior capsulorhexis h ad no effect on IOL movement with the accommodating IOL. The median near VA with distance correction was 20/60. Conclusion Pilocarpine induced a small but signi ficant forward movement of the accommodating IOL. However, the amount of movemen t was calculated to result in a refractive change of < 0.5 diopters (D) in most patients, reaching 1 D or slightly more in only single cases, with a large varia bility of movement. Neither polishing of the capsule bag nor a posterior capsulo rhexis could enhance the accommodative ability.
Purpose To measure the axial movement of an accommodating intraocular lens (IO L) induced by ciliary muscle contraction after application of pilocarpine. Desig n Randomized, controlled, patient and examiner masked trial with intrapatient co mparison. Participants and controls One hundred ten eyes of 55 patients with age -related bilateral cataract. Methods This study was divided into 3 parts. In th e first, the accommodating IOL (1CU) was compared with a 3-piece open-loop acr ylic IOL that served as the control. In the second, to assess the effect of caps ule fibrosis on the potential accommodating performance of the accommodating IOL , extensive polishing of the anterior capsule with a slit cannula was compared w ith standard surgery. In the third, the effect of a posterior capsulorhexis was compared with that of standard surgery. Anterior chamber depth (ACD) was assesse d with partial coherence interferometry, measured before and after topical appli cation of pilocarpine 2%, and near visual acuity (VA) was evaluated 3 months af ter surgery. Main outcome measure Pilocarpine-induced change in ACD. Results Th e accommodating IOL showed a forward movement under pilocarpine with a median am plitude of movement of -314 μm (95%confidence interval CI: -148 to -592), compared with the backward movement of 63 μm (95%CI: 161 to -41) for the ope n-loop control IOL (P=0.001). Capsule polishing and a posterior capsulorhexis h ad no effect on IOL movement with the accommodating IOL. The median near VA with distance correction was 20/60. Conclusion Pilocarpine induced a small but signi ficant forward movement of the accommodating IOL. However, the amount of movemen t was calculated to result in a refractive change of < 0.5 diopters (D) in most patients, reaching 1 D or slightly more in only single cases, with a large varia bility of movement. Neither polishing of the capsule bag nor a posterior capsulo rhexis could enhance the accommodative ability.
出处
《世界核心医学期刊文摘（眼科学分册）》
2005年第2期61-61,共1页
Digest of the World Core Medical Journals:Ophthalmology
