期刊文献+

老年性黄斑变性中黄斑中心凹下出血性脉络膜新生血管的手术治疗(眼部观察:第13次SST报道)

Surgery for hemorrhagic choroidal neovascular lesions of age related macular de generation: Ophthalmic findings:SST report no. 13
下载PDF
导出
摘要 To present best corrected visual acuity (BCVA) findings and other clinical ou tcomes from eyes of patients enrolled in one of the Submacular Surgery Trials (S ST) evaluating surgical removal versus observation of predominantly hemorrhagic subfoveal choroidal neovascularization (CNV) associated with age related macular degeneration. Randomized clinical trial (SST Group B Trial). Eli gible patients had subfoveal choroidal neovascular lesions greater than 3.5 disk areas (8.9 mm2)composed of at least 50%blood (either blood or CNV underlying t he center of the foveal avascular zone) and BCVA of 20/100 to light perception i n the study eye. Patients were assigned randomly at time of enrollment to observ ation or surgical removal of blood and any associated CNV. A successful outcome was defined a priori as either improvement in visual acuity (VA), no change in V A, or a decline in VA of no more than 1 line (7 letters) from baseline to the 24 month examination based on an intent to treat analysis. Of 336 patients enro lled, 168 were assigned to each treatment arm; treatment arms were balanced by b aseline characteristics. Of 1501 expected examinations 3 months through 36 month s after baseline, 1370 (91%) were performed. Loss of ≥2 lines (≥8 letters) of VA occurred in 56%of surgery eyes, versus 59%of observation eyes examined at 24 months. Although severe loss of VA was not the primary outcome of interest, s urgery more often prevented such loss: 36%in the observation arm versus 21%in the surgery arm at the 24 month examination (χ2 P=0.004). Of initially phakic eyes, the cumulative percentage that had undergone cataract surgery by 24 months was 44%in the surgery arm, compared with 6%in the observation arm. Twenty se ven eyes (16%) in the surgical arm, compared with 3 eyes (2%) in the observati on arm, had a rhegmatogenous retinal detachment (RD). Submacular surgery as perf ormed in the SST Group B Trial did not increase the chance of stable or improved VA (the primary outcome of interest) and was associated with a high risk of rhe gmatogenous RD, but did reduce the risk of severe VA loss in comparison with obs ervation. To present best corrected visual acuity (BCVA) findings and other clinical ou tcomes from eyes of patients enrolled in one of the Submacular Surgery Trials (S ST) evaluating surgical removal versus observation of predominantly hemorrhagic subfoveal choroidal neovascularization (CNV) associated with age related macular degeneration. Randomized clinical trial (SST Group B Trial). Eli gible patients had subfoveal choroidal neovascular lesions greater than 3.5 disk areas (8.9 mm2)composed of at least 50%blood (either blood or CNV underlying t he center of the foveal avascular zone) and BCVA of 20/100 to light perception i n the study eye. Patients were assigned randomly at time of enrollment to observ ation or surgical removal of blood and any associated CNV. A successful outcome was defined a priori as either improvement in visual acuity (VA), no change in V A, or a decline in VA of no more than 1 line (7 letters) from baseline to the 24 month examination based on an intent to treat analysis. Of 336 patients enro lled, 168 were assigned to each treatment arm; treatment arms were balanced by b aseline characteristics. Of 1501 expected examinations 3 months through 36 month s after baseline, 1370 (91%) were performed. Loss of ≥2 lines (≥8 letters) of VA occurred in 56%of surgery eyes, versus 59%of observation eyes examined at 24 months. Although severe loss of VA was not the primary outcome of interest, s urgery more often prevented such loss: 36%in the observation arm versus 21%in the surgery arm at the 24 month examination (χ2 P=0.004). Of initially phakic eyes, the cumulative percentage that had undergone cataract surgery by 24 months was 44%in the surgery arm, compared with 6%in the observation arm. Twenty se ven eyes (16%) in the surgical arm, compared with 3 eyes (2%) in the observati on arm, had a rhegmatogenous retinal detachment (RD). Submacular surgery as perf ormed in the SST Group B Trial did not increase the chance of stable or improved VA (the primary outcome of interest) and was associated with a high risk of rhe gmatogenous RD, but did reduce the risk of severe VA loss in comparison with obs ervation.
作者 陈立军
出处 《世界核心医学期刊文摘(眼科学分册)》 2005年第3期50-51,共2页 Digest of the World Core Medical Journals:Ophthalmology
  • 相关文献

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部