期刊文献+

特异性睑结膜炎患者泪液中ⅡA组磷脂酶A2的含量

Group ⅡA phospholipase A2 content of tears in patients with atopic blepharocon junctivitis
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摘要 Background: To determine the concentration of group IIA phospholipase A2 (GIIAPLA2) in tears of patients with atopic blepharoconjunctivitis (ABC), and to compare it with the GIIAPLA2 conce ntration of tears in age-matched healthy controls. Methods: The diagnosis of AB C was confirmed with a positive skin prick test and the presence of atopic derma titis in lids. Conjunctival brush cytology was taken, and the cells including eo sinophils, neutrophils, lymphocytes, squamous epithelial cells, columnar epithel ial cells, metaplastic changes and the goblet cells were calculated separately. The GIIAPLA2 concentration of tears was measured with a time-resolved fluoroimm unoassay in 29 patients with ABC (mean age 36.3±12.7 years) and 29 normal subje cts (mean age 37.0±12.0 years). Results: The GIIAPLA2 concentration of tears in patients with ABC was 43.8±33.0 μg/ml, and in normal subjects it was 67.1±23 .3 μg/ml. The difference was statistically significant (P=0.001 8). The concent ration of GIIAPLA2 of tears was lowest in the subgroup of patients with ABC and dry eye (25.8 ±23.6 μg/ml), whereas it was only slightly decreased in patients with ABC and normal tear secretion (56.6±33.3 μg/ml). The difference between these two subgroups was statistically significant (P=0.011). There was no statis tically significant correlation between the GIIAPLA2 concentration of tears and the quantity of different conjunctival cells gathered by the brush cytology. How ever, an almost significant correlation was found between the GIIAPLA2 concentra tion in tears and conjunctival eosinophils. Conclusions: The results indicate th at in patients with ABC the GIIAPLA2 content of tears was decreased, without any dependence on the quantity of different conjunctival cells. Background: To determine the concentration of group IIA phospholipase A2 (GIIAPLA2) in tears of patients with atopic blepharoconjunctivitis (ABC), and to compare it with the GIIAPLA2 conce ntration of tears in age-matched healthy controls. Methods: The diagnosis of AB C was confirmed with a positive skin prick test and the presence of atopic derma titis in lids. Conjunctival brush cytology was taken, and the cells including eo sinophils, neutrophils, lymphocytes, squamous epithelial cells, columnar epithel ial cells, metaplastic changes and the goblet cells were calculated separately. The GIIAPLA2 concentration of tears was measured with a time-resolved fluoroimm unoassay in 29 patients with ABC (mean age 36.3±12.7 years) and 29 normal subje cts (mean age 37.0±12.0 years). Results: The GIIAPLA2 concentration of tears in patients with ABC was 43.8±33.0 μg/ml, and in normal subjects it was 67.1±23 .3 μg/ml. The difference was statistically significant (P=0.001 8). The concent ration of GIIAPLA2 of tears was lowest in the subgroup of patients with ABC and dry eye (25.8 ±23.6 μg/ml), whereas it was only slightly decreased in patients with ABC and normal tear secretion (56.6±33.3 μg/ml). The difference between these two subgroups was statistically significant (P=0.011). There was no statis tically significant correlation between the GIIAPLA2 concentration of tears and the quantity of different conjunctival cells gathered by the brush cytology. How ever, an almost significant correlation was found between the GIIAPLA2 concentra tion in tears and conjunctival eosinophils. Conclusions: The results indicate th at in patients with ABC the GIIAPLA2 content of tears was decreased, without any dependence on the quantity of different conjunctival cells.
出处 《世界核心医学期刊文摘(眼科学分册)》 2005年第5期36-37,共2页 Digest of the World Core Medical Journals:Ophthalmology
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