摘要
Aims: To compare the macular capillary blood flow of patients with clinically significant diabetic macular oedema (DMO)-with that of non-diabetic subjects and to determine the relation between blood flow and capillary leakage in patients with DMO. Methods: The sample comprised 45 non-diabetic subjects (mean age 59 years) and 18 type 2 patients with clinically significant DMO (mean age 60 years). Macular capillary blood flow measurements were acquired using the Heidelberg retina flowmeter (HRF) and a 10° × 2.5° scan field centred on the fovea. Fluorescein angiographywas undertaken on each of the diabetic patients after the completion of HRF measurements. Results: Temporal macular capillary blood flow was significantly lower for the patients with clinically significant DMO compared with age matched non-diabetic subjects (ANCOVA, P=0.0011)-while relative nasal-temporal asymmetry of macular capillary blood flow was significantly higher (P=0.0125). Nasal-temporal asymmetry ofmacular capillary blood flowwas significantly higher for the patients with DMO and capillary leakage within the scan area (two tailed t test, P=0.0071). Macular capillary blood flow was always lower in areas of DMO and capillary leakage. Conclusion: Capillary blood flow was reduced in areas of DMO and capillary leakage, suggesting the presence of a localised perturbation of capillary blood flow regulation.
Aims: To compare the macular capillary blood flow of patients with clinically significant diabetic macular oedema (DMO)-with that of non-diabetic subjects and to determine the relation between blood flow and capillary leakage in patients with DMO. Methods: The sample comprised 45 non-diabetic subjects (mean age 59 years) and 18 type 2 patients with clinically significant DMO (mean age 60 years). Macular capillary blood flow measurements were acquired using the Heidelberg retina flowmeter (HRF) and a 10° × 2.5° scan field centred on the fovea. Fluorescein angiographywas undertaken on each of the diabetic patients after the completion of HRF measurements. Results: Temporal macular capillary blood flow was significantly lower for the patients with clinically significant DMO compared with age matched non-diabetic subjects (ANCOVA, P=0.0011)-while relative nasal-temporal asymmetry of macular capillary blood flow was significantly higher (P=0.0125). Nasal-temporal asymmetry ofmacular capillary blood flowwas significantly higher for the patients with DMO and capillary leakage within the scan area (two tailed t test, P=0.0071). Macular capillary blood flow was always lower in areas of DMO and capillary leakage. Conclusion: Capillary blood flow was reduced in areas of DMO and capillary leakage, suggesting the presence of a localised perturbation of capillary blood flow regulation.
出处
《世界核心医学期刊文摘（眼科学分册）》
2005年第6期22-22,共1页
Digest of the World Core Medical Journals:Ophthalmology
