摘要
Aims: To determine the degree to which optical coherence tomography (OCT) can distinguish differences in retinal nerve fibre layer (RNFL) thickness between ey es with mild papilloedema, pseudopapilloedema, and normal findings. Methods: 13 patients with mild papilloedema, 11 patients with congenitally crowded optic ner ves, and 17 normal subjects underwent neuro-ophthalmic examination, automated v isual field testing, and fundus photography. Spinal fluid pressure measurements were obtained in a subgroup of five patients with pseudopapilloedema and 11 pati ents with mild papilloedema. Circular OCT scans using a diameter of 3.38 mm surr ounding the optic disc were performed in each eye of patients and subjects. Fund us photographs were analysed by two observers who diagnosed crowding or papilloe dema and graded amounts of swelling. Findings were assessed by descriptive stati stics and variance analysis. Results: RNFL thickness was greater in me superior and inferior quadrants and showed a high degree of correlation between each grou p of patients and subjects. A statistically significant difference was found in mean RNFL thickness between both groups of patients with optic disc swelling and normal subjects. However, there was not a statistical difference in mean nerve fibre layer thickness between patients with papilloedema and those with congenit ally crowded optic nerves. Conclusions: OCT demonstrates measurable differences in nerve fibre layer thickness between normal subjects and patients with either papilloedema or pseudopapilloedema. However, OCT does not appear to differentiat e between those individuals with congenitally crowded optic nerves and those wit h mild papilloedema caused by increased intracranial pressure.
Aims: To determine the degree to which optical coherence tomography (OCT) can distinguish differences in retinal nerve fibre layer (RNFL) thickness between ey es with mild papilloedema, pseudopapilloedema, and normal findings. Methods: 13 patients with mild papilloedema, 11 patients with congenitally crowded optic ner ves, and 17 normal subjects underwent neuro-ophthalmic examination, automated v isual field testing, and fundus photography. Spinal fluid pressure measurements were obtained in a subgroup of five patients with pseudopapilloedema and 11 pati ents with mild papilloedema. Circular OCT scans using a diameter of 3.38 mm surr ounding the optic disc were performed in each eye of patients and subjects. Fund us photographs were analysed by two observers who diagnosed crowding or papilloe dema and graded amounts of swelling. Findings were assessed by descriptive stati stics and variance analysis. Results: RNFL thickness was greater in me superior and inferior quadrants and showed a high degree of correlation between each grou p of patients and subjects. A statistically significant difference was found in mean RNFL thickness between both groups of patients with optic disc swelling and normal subjects. However, there was not a statistical difference in mean nerve fibre layer thickness between patients with papilloedema and those with congenit ally crowded optic nerves. Conclusions: OCT demonstrates measurable differences in nerve fibre layer thickness between normal subjects and patients with either papilloedema or pseudopapilloedema. However, OCT does not appear to differentiat e between those individuals with congenitally crowded optic nerves and those wit h mild papilloedema caused by increased intracranial pressure.
出处
《世界核心医学期刊文摘（眼科学分册）》
2005年第8期40-40,共1页
Digest of the World Core Medical Journals:Ophthalmology
