摘要
BACKGROUND AND OBJECTIVE: To report the outcome of patients 28 months followin g treatment with transpupillary thermotherapy (TTT) for classic and occult choro idal neovascularization (CNV) secondary to age-related macular degeneration. PA TIENTS AND METHODS: A nonrandomized pilot trial of 36 eyes of 33 patients was pe rformed. Eyes with angiographically defined CNV, 11 predominantly classical and 25 predominantly occult, were treated with large spot diode laser (810 nm) TTT f or 1 minute, the end point being no or minimal visible change. Outcome was asses sed with bestcorrected LogMAR visual acuity, clinical examination, and fluoresce in angiography. RESULTS: Patients were observed for a mean of 28.7 months (range , 18 to 40 months). The mean change in LogMAR visual acuity for predominantly cl assic membranes was-1.91 (standard deviation [SD]=4.3) and 5 of 11 (45.5%) eye s had a loss of 3 or more LogMAR lines. Predominantly classic membranes were clo sed in 9 of 11 eyes and stabilized in 2 of 11 eyes. The mean change in LogMAR vi sual acuity for predominantly occult membranes was-1.48 (SD=6.3) and 10 of 25 ( 40%) patients had a loss of 3 lines or more. Predominantly occult CNV was stabi lized in 25 of 25 cases, and recurrence developed in 2 of 25 cases; one of the l atter developed classic CNV. CONCLUSIONS: The mediumterm results for patients tr eated with TTT for both occult and classic CNV show good stability, with little visual loss and f ew recurrences. These data confirm the original findings of this study.
BACKGROUND AND OBJECTIVE: To report the outcome of patients 28 months followin g treatment with transpupillary thermotherapy (TTT) for classic and occult choro idal neovascularization (CNV) secondary to age-related macular degeneration. PA TIENTS AND METHODS: A nonrandomized pilot trial of 36 eyes of 33 patients was pe rformed. Eyes with angiographically defined CNV, 11 predominantly classical and 25 predominantly occult, were treated with large spot diode laser (810 nm) TTT f or 1 minute, the end point being no or minimal visible change. Outcome was asses sed with bestcorrected LogMAR visual acuity, clinical examination, and fluoresce in angiography. RESULTS: Patients were observed for a mean of 28.7 months (range , 18 to 40 months). The mean change in LogMAR visual acuity for predominantly cl assic membranes was-1.91 (standard deviation [SD]=4.3) and 5 of 11 (45.5%) eye s had a loss of 3 or more LogMAR lines. Predominantly classic membranes were clo sed in 9 of 11 eyes and stabilized in 2 of 11 eyes. The mean change in LogMAR vi sual acuity for predominantly occult membranes was-1.48 (SD=6.3) and 10 of 25 ( 40%) patients had a loss of 3 lines or more. Predominantly occult CNV was stabi lized in 25 of 25 cases, and recurrence developed in 2 of 25 cases; one of the l atter developed classic CNV. CONCLUSIONS: The mediumterm results for patients tr eated with TTT for both occult and classic CNV show good stability, with little visual loss and f ew recurrences. These data confirm the original findings of this study.
出处
《世界核心医学期刊文摘（眼科学分册）》
2005年第8期60-61,共2页
Digest of the World Core Medical Journals:Ophthalmology
