摘要
Purpose: To test the correlation between optic disc topography (as measured by confocal scanning laser ophthalmoscopy [CSLO]) and retinal nerve fibre layer (R NFL) measurements (as measured by scanning laser polarimetry [SLP]) in glaucoma. Material and methods: A total of 112 patients with primary open-angle glaucoma and 88 normal individuals were enrolled in the study. All individuals underwent a thorough ophthalmic evaluation, a 24-2 full threshold Humphrey visual field, SLP with the GDx (Version 1.0.12) and CSLO with the TOPSS. Receiver operator ch aracteristic curves were created for each individual CSLO and SLP parameter. Lin ear correlations between the four best parameters from each device were calculat ed. Finally, linear correlations between the same variables, controlled for the severity of visual field damage, were calculated. Results: The best individual p arameters in the diagnosis of glaucoma for each device were cup area, vertical c up: disc ratio, cup: disc area ratio and average cup depth for CSLO, and the Num ber, maximummodulation, ellipse modulation and superior nasal for SLP. Moderate to strong correlations were observed in 62%of the pairs. However, only 6%and 1 2%of the correlations remained moderate when we controlled for the visual field mean deviation and correct pattern standard deviation, respectively. Conclusion s: The correlation between optic disc topography and RNFL measurements in glauco ma patients is moderate and highly dependent on the level of visual field loss.
Purpose: To test the correlation between optic disc topography (as measured by confocal scanning laser ophthalmoscopy [CSLO]) and retinal nerve fibre layer (R NFL) measurements (as measured by scanning laser polarimetry [SLP]) in glaucoma. Material and methods: A total of 112 patients with primary open-angle glaucoma and 88 normal individuals were enrolled in the study. All individuals underwent a thorough ophthalmic evaluation, a 24-2 full threshold Humphrey visual field, SLP with the GDx (Version 1.0.12) and CSLO with the TOPSS. Receiver operator ch aracteristic curves were created for each individual CSLO and SLP parameter. Lin ear correlations between the four best parameters from each device were calculat ed. Finally, linear correlations between the same variables, controlled for the severity of visual field damage, were calculated. Results: The best individual p arameters in the diagnosis of glaucoma for each device were cup area, vertical c up: disc ratio, cup: disc area ratio and average cup depth for CSLO, and the Num ber, maximummodulation, ellipse modulation and superior nasal for SLP. Moderate to strong correlations were observed in 62%of the pairs. However, only 6%and 1 2%of the correlations remained moderate when we controlled for the visual field mean deviation and correct pattern standard deviation, respectively. Conclusion s: The correlation between optic disc topography and RNFL measurements in glauco ma patients is moderate and highly dependent on the level of visual field loss.
出处
《世界核心医学期刊文摘（眼科学分册）》
2005年第10期14-15,共2页
Digest of the World Core Medical Journals:Ophthalmology
