谷胱甘肽S转移酶M1阳性基因型能否防止原发性开角型青光眼

May glutathione S-transferase M1 positive genotype afford protection against primary open-angle glaucoma?

Purpose: To find out whether the polymorphism at GSTM1, GSTT1 and GSTP1 loci is associated with increased susceptibility to glaucoma. Methods: We genotyped 15 3 primary open angle patients and 159 healthy controls. Genomic DNA from periphe ral blood was examined using polymerase chain reaction and defined for the genet ic polymorphisms of glutathione S-transferase. Results: The frequency of theGST M1 null genotype individuals among the glaucoma patients was significanlty highe r than in controls (54.9 vs 40.9%) with odds ratio of 1.64 (95%CI: 1.10-2.59) . The frequency of the GSTT1 and GSTP1 in both groups were not statistically dif ferent. Conclusion: The present study suggests that the GSTM1 null genotype may be a genetic risk factor for development of primary open angle glaucoma. Further associations studies in other polymorphic genes for xenobiotic-metabolizing en zymes are needed to elucidate the environmental-genetic interaction in the unde rlying cause of primary open angle glaucoma.