摘要
Purpose: To determine the concentration of group IIA phospholipase A2 (GIIAPLA 2) in tears of patients with ocular rosacea, and to compare it with GIIAPLA2 con centration in tears of age-matched healthy controls. Methods: The GIIAPLA2 conc entration in tears was measured with a time-resolved fluoroimmunoassay in 21 pa tients with ocular rosacea (mean age 55.6 ±9.2 years) and in 21 normal subjects (mean age 53.4 ±8.2 years). Conjunctival brush cytologywas carried out and eos inophils, neutrophils, lymphocytes, squamous epithelial cells, columnar epitheli al cells, metaplastic changes and goblet cells were calculated separately. Resul ts: The GIIAPLA2 concentration in tears was statistically significantly lower in patients with ocular rosacea(31.0±18.4 μg/ml, p=0.0099) and, more spe- cifically, in patients who had dry eye (25.8±15.1 μg/ml, p=0.0034), compared to that in normal controls. There was no correlation between the GIIAPLA2 conte nt of tears and the conjunctival cells collected by the brush cytology. Conclusi on: The tears of patients with dry eye symptoms due to ocular rosacea have decre ased GIIAPLA2 content. The pathogenic importance of this finding is discussed.
Purpose: To determine the concentration of group IIA phospholipase A2 (GIIAPLA 2) in tears of patients with ocular rosacea, and to compare it with GIIAPLA2 con centration in tears of age-matched healthy controls. Methods: The GIIAPLA2 conc entration in tears was measured with a time-resolved fluoroimmunoassay in 21 pa tients with ocular rosacea (mean age 55.6 ±9.2 years) and in 21 normal subjects (mean age 53.4 ±8.2 years). Conjunctival brush cytologywas carried out and eos inophils, neutrophils, lymphocytes, squamous epithelial cells, columnar epitheli al cells, metaplastic changes and goblet cells were calculated separately. Resul ts: The GIIAPLA2 concentration in tears was statistically significantly lower in patients with ocular rosacea(31.0±18.4 μg/ml, p=0.0099) and, more spe- cifically, in patients who had dry eye (25.8±15.1 μg/ml, p=0.0034), compared to that in normal controls. There was no correlation between the GIIAPLA2 conte nt of tears and the conjunctival cells collected by the brush cytology. Conclusi on: The tears of patients with dry eye symptoms due to ocular rosacea have decre ased GIIAPLA2 content. The pathogenic importance of this finding is discussed.
出处
《世界核心医学期刊文摘（眼科学分册）》
2005年第11期13-13,共1页
Digest of the World Core Medical Journals:Ophthalmology
