摘要
Aim: To determine the anatomical site and extent of electrophysiological dysfu nction in patients with ethambutol associated visual loss. Methods: A comparativ e case series. Four patients with ethambutol associated visual loss underwent mu ltifocal electroretinography (mERG). Two patients had advanced visual loss while two had early signs of toxicity. The N1-P1, N1, P1 amplitudes, N1, and P1 late ncies were compared to 10 age and sex matched controls. Results: mERG abnormalit ies were detected in the ethambutol treated patients. The N1 amplitude was signi ficantly lower in the ethambutol treated patients than in the control group. Con clusion: Ethambutol is possibly toxic to the retina, and not only the optic nerv e. The multifocal ERG may be of value to diagnose and monitor patients taking et hambutol.
Aim: To determine the anatomical site and extent of electrophysiological dysfu nction in patients with ethambutol associated visual loss. Methods: A comparativ e case series. Four patients with ethambutol associated visual loss underwent mu ltifocal electroretinography (mERG). Two patients had advanced visual loss while two had early signs of toxicity. The N1-P1, N1, P1 amplitudes, N1, and P1 late ncies were compared to 10 age and sex matched controls. Results: mERG abnormalit ies were detected in the ethambutol treated patients. The N1 amplitude was signi ficantly lower in the ethambutol treated patients than in the control group. Con clusion: Ethambutol is possibly toxic to the retina, and not only the optic nerv e. The multifocal ERG may be of value to diagnose and monitor patients taking et hambutol.
出处
《世界核心医学期刊文摘（眼科学分册）》
2005年第11期25-26,共2页
Digest of the World Core Medical Journals:Ophthalmology
