摘要
Aims: To evaluate the effect of tranexamic acid on early postvitrectomy haemor rhage in diabetic patients. Methods: In a clinical trial, 62 diabetic patients s cheduled for vitrectomywere randomly assigned to two groups. The treatment group (32 eyes) received two doses of tranexamic acid (10 mg/kg) shortly before and a fter the operation intravenously, continued orally for 4 days (20 mg/kg/8 hours) . The control group (30 eyes) received nomedication. Bothmedia clarity and visua l acuity were compared during 4 weeks. Results: Four weeks after surgery visual acuity was low (≤1 metre counting fingers) in 21.4%, moderate (> 1 metre count ing fingers but < 20/200) in 14.3%, and good (≥20/200) in 64.3%of the treated group. Corresponding figures in the control group were 26.1%, 26.1%, and 47.8 %, respectively. These differences were of no statistical significance. The rat io of mild to severe vitreous haemorrhage during the first 4 days and after 4 we eks was 79%to 21%and 82%to 18%in the treatment group and 76.7%to 23.3%and 78.3%to 21.7%in the control group respectively,which showed no statistically s ignificant difference. Conclusion: Tranexamic acid, with the method of administr ation in this study, had no effect on reducing early postvitrectomy haemorrhage in diabetic patients.
Aims: To evaluate the effect of tranexamic acid on early postvitrectomy haemor rhage in diabetic patients. Methods: In a clinical trial, 62 diabetic patients s cheduled for vitrectomywere randomly assigned to two groups. The treatment group (32 eyes) received two doses of tranexamic acid (10 mg/kg) shortly before and a fter the operation intravenously, continued orally for 4 days (20 mg/kg/8 hours) . The control group (30 eyes) received nomedication. Bothmedia clarity and visua l acuity were compared during 4 weeks. Results: Four weeks after surgery visual acuity was low (≤1 metre counting fingers) in 21.4%, moderate (> 1 metre count ing fingers but < 20/200) in 14.3%, and good (≥20/200) in 64.3%of the treated group. Corresponding figures in the control group were 26.1%, 26.1%, and 47.8 %, respectively. These differences were of no statistical significance. The rat io of mild to severe vitreous haemorrhage during the first 4 days and after 4 we eks was 79%to 21%and 82%to 18%in the treatment group and 76.7%to 23.3%and 78.3%to 21.7%in the control group respectively,which showed no statistically s ignificant difference. Conclusion: Tranexamic acid, with the method of administr ation in this study, had no effect on reducing early postvitrectomy haemorrhage in diabetic patients.
出处
《世界核心医学期刊文摘（眼科学分册）》
2005年第11期32-33,共2页
Digest of the World Core Medical Journals:Ophthalmology
