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光学相干断层成像术与超声生物显微镜用于窄前房角检测的比较性研究 被引量:3

Comparison of optical coherence tomograp-hy and ultrasound biomicroscopy for detection of narrow anterior chamber angles
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摘要 Objective: To assess the accuracy of classification of narrow anterior chamber (AC) angles using quantitative imaging by optical coherence tomography (OCT) and ultrasound biomicroscopy (UBM). Design: Observational comparative study. Methods: A high-speed (4000 axial scans/s) anterior segment OCT prototype was developed using a 1.3- μ m light source. Seventeen normal subjects (17 eyes) and 7 subjects (14 eyes)-with narrow angle glaucoma were enrolled. All subjects underwentg onioscopy, OCT, and UBM. Quantitative AC angle parameters (angle opening distance, angle recess area, and the trabecular-iris space area [a new parameter we have defined])-were measured from OCT and UBM images using proprietary processing software. Main Outcome Measures: Specificity and sensitivity in identifying narrow angles with image-derived AC angle parameters. Results: Eight of 31 eyes were classified as having narrow angles (Shaffer grade ≤ 1 in all quadrants). The AC angle parameters measured by both OCT and UBM had similar mean values, reproducibility, and sensitivity specificity profiles. Both OCT and UBM showed excellent performance in identifying eyes with narrow angles. Areas under the receiver operating characteristic curves for these parameters were all in the range of 0.96 to 0.98. Conclusions: Optical coherence tomography was similar to UBM in quantitative AC angle measurement and detection of narrow angles. In addition, it was easier to use and did not require contact with the eye. Optical coherence tomography is a promising method for screening individuals at risk for narrow angle glaucoma. Objective: To assess the accuracy of classification of narrow anterior chamber (AC) angles using quantitative imaging by optical coherence tomography (OCT) and ultrasound biomicroscopy (UBM). Design: Observational comparative study. Methods: A high-speed (4000 axial scans/s) anterior segment OCT prototype was developed using a 1.3- μ m light source. Seventeen normal subjects (17 eyes) and 7 subjects (14 eyes)-with narrow angle glaucoma were enrolled. All subjects underwentg onioscopy, OCT, and UBM. Quantitative AC angle parameters (angle opening distance, angle recess area, and the trabecular-iris space area [a new parameter we have defined])-were measured from OCT and UBM images using proprietary processing software. Main Outcome Measures: Specificity and sensitivity in identifying narrow angles with image-derived AC angle parameters. Results: Eight of 31 eyes were classified as having narrow angles (Shaffer grade ≤ 1 in all quadrants). The AC angle parameters measured by both OCT and UBM had similar mean values, reproducibility, and sensitivity specificity profiles. Both OCT and UBM showed excellent performance in identifying eyes with narrow angles. Areas under the receiver operating characteristic curves for these parameters were all in the range of 0.96 to 0.98. Conclusions: Optical coherence tomography was similar to UBM in quantitative AC angle measurement and detection of narrow angles. In addition, it was easier to use and did not require contact with the eye. Optical coherence tomography is a promising method for screening individuals at risk for narrow angle glaucoma.
出处 《世界核心医学期刊文摘(眼科学分册)》 2005年第12期24-25,共2页 Digest of the World Core Medical Journals:Ophthalmology
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