摘要
Objectives: We scanned human chromosome 17 to verify previous studies o n the c hromosome as well as to explore possible new loci of essential hypertension in a Chinese Han population. Methods: A genomic scan of chromosome 17 with 15 micros atellite markers was conducted in a total of 757 individuals from 147 Chinese hy pertension pedigrees. We used three softwares to analyse hypertension as a quali tative trait and blood pressure as quantitative phenotypes linkage analyses in t he North group (406 individuals from 78 northern families), the South group (351 individuals from 69 southern families) and the combined group of the Chinese po pulation separately. Results: For qualitative trait, a 7-cM (centiMorgan) inter val flanked by D17S831 (7 cM) and D17S938 (15 cM) showed suggestive linkage resu lts (P < 0.00074) in the southern population by SAGE/SIBPAL2. For blood pressure (BP) quantitative phenotypes, the regions with lowest P values in SAGE and high est logarithm of odds (LOD) scores in SOLAR just overlapped this 7-cM interval in the South group for both systolic blood pressure (SBP) and diastolic blood pr essure(DBP), though these peaks did not yet reach to the suggestive linkage crit eria(P =0.00074, LOD score=2.2). In the northern population, in a region around 75.0 cM(D17S787) a peak was found with non-parametric-linkage (NPL) score 1.82 for qualitative trait using GENEHUNTER. Conclusions: In the southern population of China, our results demonstrate that a 7-cM interval region flanked by D17S8 31 (7 cM) and D17S938 (15 cM) is suggestively linked with hypertension.
Objectives: We scanned human chromosome 17 to verify previous studies o n the c hromosome as well as to explore possible new loci of essential hypertension in a Chinese Han population. Methods: A genomic scan of chromosome 17 with 15 micros atellite markers was conducted in a total of 757 individuals from 147 Chinese hy pertension pedigrees. We used three softwares to analyse hypertension as a quali tative trait and blood pressure as quantitative phenotypes linkage analyses in t he North group (406 individuals from 78 northern families), the South group (351 individuals from 69 southern families) and the combined group of the Chinese po pulation separately. Results: For qualitative trait, a 7-cM (centiMorgan) inter val flanked by D17S831 (7 cM) and D17S938 (15 cM) showed suggestive linkage resu lts (P < 0.00074) in the southern population by SAGE/SIBPAL2. For blood pressure (BP) quantitative phenotypes, the regions with lowest P values in SAGE and high est logarithm of odds (LOD) scores in SOLAR just overlapped this 7-cM interval in the South group for both systolic blood pressure (SBP) and diastolic blood pr essure(DBP), though these peaks did not yet reach to the suggestive linkage crit eria(P =0.00074, LOD score=2.2). In the northern population, in a region around 75.0 cM(D17S787) a peak was found with non-parametric-linkage (NPL) score 1.82 for qualitative trait using GENEHUNTER. Conclusions: In the southern population of China, our results demonstrate that a 7-cM interval region flanked by D17S8 31 (7 cM) and D17S938 (15 cM) is suggestively linked with hypertension.
