摘要
Objective: To examine the effects of current and past blood pressure on retina l arteriolar diameter in a general older population. Design: Cross-sectional an d longitudinal studies. Setting: Population-based cohort study of older residen ts from an area west of Sydney, Australia. Participants: Two thousand three hund red and thirty-five individuals (n=2335) (aged≥54 years) who attended the 5-y ear follow-up Blue Mountains Eye Study during 1997-99. Main outcome measures: A computer-assisted method measured vessel diameters from digitized right eye r etinal photographs. The narrowest quintile of central retinal arteriolar equival ent or arteriole-to-venule ratio (AVR) defined generalized arteriolar narrowin g. Blood pressure was measured using a mercury sphygmomanometer. Results: After simultaneous adjustment for age, sex, body mass index, smoking and current or pa st blood pressure, elevated levels of both current and past blood pressure were associated with narrower retinal arterioles <<Ptrend=0.009 and 0.007 for current and past systolic blood pressure (SBP), respectively>> and lower AVR <<Ptrend= 0.0 01 and 0.0009 for current and past diastolic blood pressure (DBP), respectively>> . Generalized arteriolar narrowing was associated with both current blood pressu re <<adjusted odds ratio (OR) 2.4, 95%confidence interval (CI) 1.5-3.8 for the highest versus lowest quintile of current DBP>> and past blood pressure (adjusted OR 1.7, 95%CI 1.1-2.6, for the highest versus lowest quintile of past DBP). H ypertension duration or control status at baseline had no additional effect on a rteriolar diameter after adjusting for current blood pressure. Conclusions: Our data document the independent effects of both current and past blood pressure on small vessel calibre in the retina, suggesting that retinal arteriolar narrowin g may result from the cumulative effects of long-standing hypertension.
Objective: To examine the effects of current and past blood pressure on retina l arteriolar diameter in a general older population. Design: Cross-sectional an d longitudinal studies. Setting: Population-based cohort study of older residen ts from an area west of Sydney, Australia. Participants: Two thousand three hund red and thirty-five individuals (n=2335) (aged≥54 years) who attended the 5-y ear follow-up Blue Mountains Eye Study during 1997-99. Main outcome measures: A computer-assisted method measured vessel diameters from digitized right eye r etinal photographs. The narrowest quintile of central retinal arteriolar equival ent or arteriole-to-venule ratio (AVR) defined generalized arteriolar narrowin g. Blood pressure was measured using a mercury sphygmomanometer. Results: After simultaneous adjustment for age, sex, body mass index, smoking and current or pa st blood pressure, elevated levels of both current and past blood pressure were associated with narrower retinal arterioles <<Ptrend=0.009 and 0.007 for current and past systolic blood pressure (SBP), respectively>> and lower AVR <<Ptrend= 0.0 01 and 0.0009 for current and past diastolic blood pressure (DBP), respectively>> . Generalized arteriolar narrowing was associated with both current blood pressu re <<adjusted odds ratio (OR) 2.4, 95%confidence interval (CI) 1.5-3.8 for the highest versus lowest quintile of current DBP>> and past blood pressure (adjusted OR 1.7, 95%CI 1.1-2.6, for the highest versus lowest quintile of past DBP). H ypertension duration or control status at baseline had no additional effect on a rteriolar diameter after adjusting for current blood pressure. Conclusions: Our data document the independent effects of both current and past blood pressure on small vessel calibre in the retina, suggesting that retinal arteriolar narrowin g may result from the cumulative effects of long-standing hypertension.
