摘要
Background: The infection with Chlamydia pneumoniae (Cp)has been claimed to as sociate with coronary artery disease (CAD). However, the seroepidemiological stu dy of association between Cp infection and CAD still remains a source of controv ersy. The aim of the present study is to investigate the possible association of Cp infection with CAD in Chinese mainland population and the potential role of Cp infection combined with the traditional risk factors in CAD. Methods: 1422 ho spitalized patients with angiographically demonstrated CAD and 297 controls were recruited and tested for specific Cp IgG with enzyme linked immunoassay (ELISA ). Results: The prevalence of Cp IgG seropositivity in patients with CAD was sig nificantly higher than that in controls(31.1%vs. 24.9%, P=0.035). Unadjusted o dds ratios (OR) and 95%confidence intervals (CI) for CAD with the presence of s eropositivity of IgG to Cp was 1.4 (1.0-1.8). After full adjustment for possibl e confounders on multiple logistic regression analysis, only a weak association of Cp infection with CAD was found. The adjusted OR(95%CI) for CAD associated w ith Cp infection was 1.3 (0.95-1.71, P=0.1). To further delineate the potential role of Cp infection in CAD, we divided subjects into seropositive (n=516) and seronegative (n=1203) groups according to their Cp IgG status. Notably, the adju sted OR(95%CI) for CAD associated with smoking was 4.0(1.8-8.6) in the seropos itive group, 0.9 (0.5-1.4) in the seronegative group, indicating that smoking c an significantly increase the risk of CAD in subjects with Cp infection. Conclus ions: Cp infection is not strongly associated with CAD in Chinese mainland popul ation; however, smoking increases the risk of CAD in those with Cp infection.
Background: The infection with Chlamydia pneumoniae (Cp)has been claimed to as sociate with coronary artery disease (CAD). However, the seroepidemiological stu dy of association between Cp infection and CAD still remains a source of controv ersy. The aim of the present study is to investigate the possible association of Cp infection with CAD in Chinese mainland population and the potential role of Cp infection combined with the traditional risk factors in CAD. Methods: 1422 ho spitalized patients with angiographically demonstrated CAD and 297 controls were recruited and tested for specific Cp IgG with enzyme linked immunoassay (ELISA ). Results: The prevalence of Cp IgG seropositivity in patients with CAD was sig nificantly higher than that in controls(31.1%vs. 24.9%, P=0.035). Unadjusted o dds ratios (OR) and 95%confidence intervals (CI) for CAD with the presence of s eropositivity of IgG to Cp was 1.4 (1.0-1.8). After full adjustment for possibl e confounders on multiple logistic regression analysis, only a weak association of Cp infection with CAD was found. The adjusted OR(95%CI) for CAD associated w ith Cp infection was 1.3 (0.95-1.71, P=0.1). To further delineate the potential role of Cp infection in CAD, we divided subjects into seropositive (n=516) and seronegative (n=1203) groups according to their Cp IgG status. Notably, the adju sted OR(95%CI) for CAD associated with smoking was 4.0(1.8-8.6) in the seropos itive group, 0.9 (0.5-1.4) in the seronegative group, indicating that smoking c an significantly increase the risk of CAD in subjects with Cp infection. Conclus ions: Cp infection is not strongly associated with CAD in Chinese mainland popul ation; however, smoking increases the risk of CAD in those with Cp infection.
