摘要
背景:心脏瓣膜病与脂质状况的相关性可能很重要,如在主动脉瓣狭窄病例中所见。然而,目前尚未详细研究过其他瓣膜疾病,尤其是二尖瓣狭窄(MS)与脂质状况的可能关联性。作者拟在一组MS患者中探寻超声心动图二尖瓣Wilkins评分与脂质参数之间的可能相关性,这些患者因可能需行经皮球囊瓣膜成形术而被转诊。
Background: Association of valvular heart disease and lipid profile might be important as in the case of aortic stenosis. However, it has not been so far considered in detail the probable association of other valvular diseases, particularly of mitral stenosis(MS) with lipid profile. In our study, we aimed to search possible association of echocardiographic mitral valve score, evaluated according to Wilkins score, with lipid parameters in a group of patients with mitral stenosis, who were referred for possible percutaneous balloon valvuloplasty. Material and Method: We retrospectively reviewed 401 patients(316 female, 85 male), who were referred as possible candidates for PMBV, with moderate to severe MS of predominantly rheumatic origin. Mitral valve was evaluated according to Wilkins score by an experienced author as indicated. Results: Mean age of all patients was 36.6±11.3 years, and was not different in both genders. Mean mitral valve area was 1±0.1 mm2. Considering all patients, total Wilkins score was significantly, but mildly correlated with ratio of total/HDL cholesterol ratio(r=0.174, p=0.02). Presence of more than one recurrent attack of rheumatic fever, narrow mitral valve area, high total/HDL cholesterol and being male were independent predictors of poor echocardiographic Wilkins score(>8). Conclusion: We think that Wilkins echocardiographic score of mitral stenosis, particularly of leaflet thickening, might well be associated with serum lipids, probably as the same extent does aortic stenosis.
