摘要
目的:尽管已有证据一致证实,明显甲状腺功能亢进和明显甲状腺功能减退均可导致高血压发病风险增高,但是亚临床甲状腺功能亢进和血压之间的关系却尚未引起足够的注意。方法:波美拉尼亚健康状况研究是一项在以前碘缺乏地区实施的基于人群的研究。本研究共纳入4087例无明显甲状腺功能亢进或血清促甲状腺激素水平升高受试者(女性2050例)。
OBJECTIVE:Although evidence for an increased risk of hypertension in both overt hyperthyroidism and overt hypothyroidism is consistent, the relation between subclinical hyperthyroidism and blood pressure has not yet received sufficient attention. METHODS: The Study of Health in Pomerania is a population-based survey in Germany that was conducted in a previously iodine-deficient region. A study population of 4087 subjects(2050 women) without overt hyperthyroidism or increased serum thyrotropin levels was available for the present study. Serum thyrotropin levels< 0.25 mIU/l and< 0.1 mIU/l were considered decreased and suppressed, respectively. RESULTS: Multivariable analyses revealed lower adjusted mean values for systolic blood pressure in subjects with decreased[132.9 mmHg, 95%confidence interval(CI)=131.1 mmHg; 134.8 mmHg] versus normal serum thyrotropin levels(135.0 mmHg, 95%CI=134.4 mmHg; 135.6 mmHg, P=0.04). The adjusted mean values for diastolic blood pressure and pulse pressure did not differ significantly between both groups. Analyses that were performed after all subjects receiving antihypertensive medications had been excluded did not reveal any statistically significant associations between decreased serum thyrotropin levels and the endpoints investigated. There was also no association of suppressed serum thyrotropin levels with blood pressure or hypertension. CONCLUSION: It is concluded that subclinical hyperthyroidism, as demonstrated by decreased as well as suppressed serum thyrotropin levels and serum free thyroid hormone levels within the reference range, is not associated with hypertension.
