摘要
背景:高敏C-反应蛋白(hsCRP)被认为是动脉粥样硬化风险的独立预测因素。此外,单性别横断面研究表明心肺适能与hsCRP呈负相关。作者的目的是明确在有心血管疾病危险的混合性别人群中,通过运动训练调整心肺适能是否引起hsCRP的改变。
Background: High-sensitivity C-reactive protein(hsCRP) is promoted as an independent predictor of atherosclerotic risk. In addition, cardiorespiratory fitness is inversely related to hsCRP in single-sex cross-sectional analyses. Our objective was to determine if modulating fitness with exercise training imposes changes in high-sensitivity C-reactive protein in a mixed-sex population at risk for cardiovascular disease. Methods: We studied baseline and postintervention plasma hsCRP in 193 sedentary, overweight to mildly obese, dyslipidemic men and women who were randomized to 6 months of inactivity or 1 of 3 aerobic exercise groups: low amount-moderate intensity(energy equivalent of approximately 19.3 km/wk at 40%-55%peak Vo2), low amount-high intensity(energy equivalent of approximately 19.3 km/wk at 65%-80%peak Vo2), or high amount-high intensity(energy equivalent of approximately 32.2 km/wk at 65%-80%peak Vo2). Results: At baseline, the study population was at intermediate to high cardiovascular risk as defined by hsCRP. Cardiorespiratory fitness was inversely related to hsCRP(P < .001) even after adjusting for significant and expected sex differences. Fitness, hormone replacement therapy use, and high-density lipoprotein cholesterol accounted for the sex difference in baseline hsCRP. Fitness, high-density lipoprotein cholesterol, fasting insulin, hormone replacement therapy, and visceral adiposity were all independent predictors for baseline hsCRP(r2=0.34 for the entire model, P < .0001). However, despite significant improvements in fitness, visceral adiposity, subcutaneous adiposity, and insulin sensitivity, hsCRP did not change in response to exercise training(P > .20). Conclusions: Cardiorespiratory fitness is inversely related to hsCRP independent of sex and accounts for most of the large sex disparity in hsCRP. Nonetheless, in the absence of a significant change in diet, 6 months of aerobic exercise training does not produce a significant change in hsCRP in an at-risk population.
