摘要
维生素D缺乏是骨质疏松症以及其他慢性疾病(包括1型糖尿病、高血压、代谢综合征和缺血性心脏病)的危险因素。胆固醇与维生素D均参与7-脱氢胆固醇代谢途径。本研究旨在评价阿托伐他汀对急性缺血性心脏病患者维生素D水平可能产生的影响。共纳入83例急性冠状动脉综合征患者(52例男性和31例女性;75例急性心肌梗死以及8例不稳定型心绞痛)。诊断明确后患者接受阿托伐他汀治疗作为二级预防措施。
Vitamin D deficiency is a risk factor for osteoporosis and other chronic diseases, including type 1 diabetes, hypertension, metabolic syndrome, and ischemic heart disease. Cholesterol and vitamin D share the 7-dehydrocolesterol metabolic pathway. This study evaluated the possible effect of atorvastatin on vitamin D levels in patients with acute ischemic heart disease. Eighty-three patients(52 men and 31 women) with an acute coronary syndrome(75 with acute myocardial infarction and 8 with unstable angina) were included. After diagnosis, patients received atorvastatin as secondary prevention. Serum vitamin D was measured by high-performance liquid chromatography at baseline and at 12 months. Atorvastatin treatment produced a statistically significant decrease in cholesterol and triglyceride levels and an increase in vitamin D levels(41± 19 vs 47± 19 nmol/L, p=0.003). Vitamin D deficiency was decreased by 75% to 57% at 12 months. In conclusion, atorvastatin increases vitamin D levels. This increase could explain some of the beneficial effects of atorvastatin at the cardiovascular level that are unrelated to cholesterol levels.
