老年肿瘤患者红细胞与淋巴细胞协同抗肿瘤作用的研究

<title>Anticancer effect of erythrocytes and lymphocytes in aged patients with tumors

目的:评价老年肿瘤患者红细胞与淋巴细胞协同抗肿瘤能力。方法:应用红细胞与淋巴细胞免疫粘附花环试验,检测了47例老年肿瘤患者红细胞与淋巴细胞混合花环形成情况。结果:老年肿瘤患者与正常对照相比红细胞与淋巴细胞围攻肿瘤细胞花环率降低(P<0.01)。不论是肿瘤组还是正常人,红细胞都有促进淋巴细胞围攻肿瘤细胞的作用,但肿瘤患者的红细胞对淋巴细胞粘附肿瘤细胞的促进作用低于对照组。结论:老年肿瘤患者的红细胞与淋巴细胞协同抗肿瘤的免疫功能低于正常对照组。

<Abstrcat>Objective:To study the anticancer activity of erythrocytes and lymphocytes in aged patients with tumors.Methods:The tests of lymphocytestumor cells rosette, erythrocyteslymphocytestumors cells rosette and erythrocytetumor cells rosette in 47 aged patients with different kinds of tumors were applied.Results:Erythrocytes and lymphocytes of the aged patients with tumors had less immunoadhering to cancer cells than those of normal groups (P<0.01).The effect of erythrocytes to improve lymphocytes immunoadhering to cancer cells in these patients was lower than that of the normal groups(P<0.01).Conclusion:Anticancer immunity of erythrocytes and lymphocytes is lower in aged patients with tumor than that of the normal.