浅低温不停跳心内直视手术心肌酶活性分析

The study of myocardial enzymatic changes on beating heart under mild hypothermic cardipoulmonary bypass

目的 :观察浅低温不停跳心内直视手术与冷停跳手术心肌酶学的变化 ,明确不停跳手术对心肌的保护作用。方法 :6 0例心内直视手术病人随机分成实验组 (不停跳组 )和对照组 (冷停跳组 ) ,每组 30例。两组分别于体外循环前 5min ,体外循环后 2、 6、 2 4、 4 8h采血测定心肌酶 (CK、CK MB、LDH、AST)。结果 :对照组再灌注后CK、CK MB、LDH、AST明显增高 ,与实验组同时点相比差异有显著意义 (P <0 0 1)。结论 :浅低温不停跳手术能降低心脏手术患者CK、CK MB、LDH及AST活性 。

Objective:In this study, myocardial enzymatic changes between beating heart surgery and cold cardioplegic heart surgery were observed, to evaluate the portective effects on myocardium of beating heart surgery Methods:60 patients were randomly divided into an experimental group (beating heart surgery group) and a control group (cold cardioplegic arrest heart surgery group), with 30 patients in each group In two groups, blood was sampled 5 minute before cardiopulmony bypass (CPB), 2?6?24?48 h after CPB and survey serum myocardial enzymes Results:In control group, the level of CK?CK MB?LDH?AST significantly increased during CPB After reperfusion CK?CK MB?LDH and AST were significantly higher in control group than those in experimental group ( P <0 01) Conclusion:The beating heart surgery does not increase patients serum CK?CK B?LDH and AST activities, implying better myocardial protection