超声引导乙醇消融治疗原发性肝癌的临床研究

Clinical investigation of percutaneous ethanol injection ablation under color Doppler flow imaging for primary liver carcinoma

目的:探讨超声引导下无水乙醇消融治疗原发性肝癌的疗效。方法:应用彩色多普勒超声引导经皮肝内肿瘤穿刺注射无水乙醇治疗原发性肝癌24例,按肿瘤直径每1.0 cm注入乙醇1.5~2.0 mL计算注射量,每周1~2次,4~6次为1个疗程。结果:甲胎蛋白(AFP)4例转阴,10例下降50%以上;治疗3个月后彩超及CT复查,4例肿瘤完全消失,16例肿瘤均有不同程度缩小,总有效率83.3%。1年生存率79.2%,2年生存率66.7%。结论:超声引导乙醇消融治疗早期原发性肝癌局部疗效较好,费用低廉,安全实用。

Objective:To evaluate the efficacy of percutaneous ethanol injection ablation under color Doppler flow imaging(CDFI)for primary liver carcinoma.Methods:Under the ultrasonic guidance,24 patients with primary liver carcinoma underwent percutaneous ethanol injection ablation,and ethanol was injected slowly into the center of tumors.According to every 1 cm diameter of tumor,1.5 to 2 mL ethanol was injected.With once or twice in a week,four to six successive injections were finished during a full period of treatment.Results:The serum AFP was decreased significantly in 14 patients.In 4 lesions,CDFI and CT examination 3 months after the treatment showed complete necrosis of tumor.In another 16 lesions,the lesion was partly ablated.1 and 2 year cumulative recurrence rate were 79.2% and 66.7%.Conclusion:Percutaneous ethanol injection ablation under the guidance of CDFI is an effective,cheap and safe treatment for primary liver carcinoma.