不同剂量辛伐他汀对急性冠状动脉综合征患者冠状动脉介入术后炎症因子的影响

Effect of sivastatin on inflammatory cytokins level in patients with acute coronary syndrome after percutaneous coronary intervention

目的:研究不同剂量辛伐他汀治疗对急性冠状动脉综合征(ACS)患者急诊经皮冠状动脉介入治疗(PCI)术后炎症因子水平的影响。方法:入选52例ACS患者,随机分为辛伐他汀20mg组和40mg组,共观察4周。两组患者PCI术前、术后14天、28天分别抽血查高敏C反应蛋白(hs-CRP)、纤维蛋白原(FIB)水平。结果:PCI术后第14天、第28天时40mg辛伐他汀组血清hs-CRP和FIB水平显著低于20mg辛伐他汀组。第14天时大剂量组和常规剂量组分别是hs-CRP(3.73±2.5)mg/Lvs(5.49±2.90)mg/L(P【0.05),FIB(2.67±0.98)g/Lvs(3.27±1.05)g/L(P【0.05)。第28天时两组分别是hs-CRP(1.99±1.07)mg/Lvs(3.10±1.78)mg/L(P【0.01),FIB(1.91±0.78)g/Lvs(2.39±0.71)g/L(P【0.05)。结论:较大剂量辛伐他汀能更显著降低血清hs-CRP和FIB水平,抑制PCI术后的炎症反应。

Objective:To explore effect of different dose sivastatin on the inflammatory cytokins level in the patients with cacute coronary syndrome(ACS)who received percutaneous coro-nary intervention(PCI).Methods:Fifty-two patients were divided into two groups.The patients in group 1 received sivastatin 20mg/d and in group 2 received sivastatin 40mg/d.The concentrations of high sensitive reactive protein(hs-CRP)and fibrinogen(FIB)were detected before PCI and on the 14th day and 28th day after PCI.Results:At the 14th day,the cytokins concentrations of group 1 were significantly lower than those of group 2 respectively [hs-CRP(3.73±2.5)mg/L vs(5.49±2.90)mg/L(P<0.05),FIB(2.67 ±0.98)g/L vs(3.27±1.05)g/L(P<0.05)].At the 28th day,the cytokins concentrations of group 1 were significantly lower than those of group 2 respectively [hs-CRP(1.99±1.07)mg/L vs(3.10 ±1.78)mg/L(P<0.01),FIB(1.91±0.78)g/L vs(2.39±0.71)g/L(P <0.05)].Conclusion:The larger dose of sivastatin can greatly decreases the level of hs-CRP and FIB,that is greatly repressing the inflammatory reaction after PCI.