过敏性紫癜性肾炎患儿血浆TNF-α、TGF-β1水平变化及临床意义

Changes and clinical significance of Tumor Necrosis Factor-α and Transforming Growth Factor-β1 in children with Henoch-Schonlein purpura nephritis

目的:探讨过敏性紫癜(HSP)、紫癜性肾炎(HSPN)患儿血浆TNF-α和TGF-β1水平变化及其在HSPN肾脏病理损害中的作用。方法:32例HSP患儿、38例HSPN患儿和20例健康对照组儿童采用ELISA法测定其血浆TNF-α和TGF-β1水平,比较其与HSPN患儿肾脏病理损害程度的相关性分析。结果:1.HSP、HSPN患儿血浆TNF-α和TGF-β1水平均高于对照组,其中HSPN组血浆TNF-α和TGF-β1水平高于HSP无肾损害组(P【0.01)。2.HSPN组患儿血浆TNF-α和TGF-β1水平变化与其肾脏病理损害评分呈正相关(P【0.01)。3.HSPN组患儿血浆TNF-α水平和TGF-β1水平呈正相关(P【0.01)。结论:TNF-α和TGF-β1水平升高参与了HSPN的发生、发展过程,且与临床肾脏病变程度密切相关,检测患儿血浆TNF-α和TGF-β1水平对于估计预后具有一定的参考价值。

objective:To investigate the level changes and clinical significance of Tumor Necrosis Factor-α(TNF-α)and Transforming Growth Factor-β1(TGF-β1)and their effects on kidney lession in children with Henoch-Schonlein purpura ne-phritis.Method:The concentration of TNF-αand TGF-β1 were measured in 32 cases HSP patients,38 cases HSPN patients and 25 controls by using ELISA.We compared the level of TNF-αand TGF-β1with kidney pathology grade in the group of HSPN.Re-sults 1.The concentration of TNF-αand TGF-β1 in paitents were more higher than normal control groop(P<0.01),and the level of TNF-α and TGF-β1 in HSPN was higher than the group of HSP.2.The level of TNF-α and TGF-β1 had positive correlation with kidney pathology grade in the group of HSPN(P<0.01).3.The level of TNF-α had positive correlation with that of TGF-β1 in HSPN(P<0.01).Conclusion:The level of TNF-αand TGF-β1 play an important role in the pathogenesis and progression of HSPN.TNF-α and TGF-β1are valuable in evaluating the prognosis of HSPN.