舍曲林治疗急性心肌梗死伴抑郁患者的近期疗效观察

Therapeutic efficacy of antidepression sertraline in patients with AMI and depression

目的:观察抗抑郁药舍曲林治疗急性心肌梗死(AMI)伴抑郁患者的近期疗效及安全性。方法:58例急性心肌梗死伴抑郁的患者随机分为治疗组30例和对照组28例。对照组在常规心脏药物治疗、心理治疗基础上予氟西汀治疗;治疗组在对照组的基础上加服抗抑郁药舍曲林,每天1次,共4周。用汉密尔顿抑郁量表(HAMD)评定临床疗效,副反应量表(TESS)评定不良反应。结果:与对照组比较,治疗组心肌缺血明显改善,心绞痛复发率及发生急性心肌梗死比例低,差异有显著意义(P【0.05)。结论:抗抑郁治疗药舍曲林能明显提高急性心肌梗死伴抑郁患者的近期疗效。

Objective:To observe the therapeutic efficacy of antidepressive,sertraline in patients with AMI and depression.Methods:58 AMI and depression patients were randomly divided into a therapy group(n=30)and control group(28).Patients in control group were treated with regular cardiac medicine therapy and psychotherapy and fluoxetine.Patients in therapy group were treated with an administration of antidepressive sertraline once a day on the basic of regular cardiac medicine therapy and psycho-therapy for 4 weeks.Hamilton Anxiety Rating Scale(HAMA)and Treatment Emergent Symptom Scale(TESS)were used to evaluate curative effect and adverse reactions.Results:AMI and depression in the therapy group were significantly improved.The recurrence rate of angina and incidence ratio of acute myocardial infarction in the therapy group was low.There was significant difference in comparison with the control group(P<0.05).Conclusion:Antidepressive sertraline can markedly improve the therapeutic efficacy inpatients with AMI and depression.