影响滤过道瘢痕化的主要信号传导通路

青光眼滤过性手术后滤过道的瘢痕化是手术失败的主要原因,它以Tenon’s囊成纤维细胞转化为肌成纤维细胞持续存在并产生大量的细胞外基质为主要特征。多种细胞因子通过TGF-β/Smad,Rho-ROCK,MAPK以及NF-κB等信号通路调控瘢痕化的进程,利用RNA干扰技术和其它方法调节信号传导途径中的关键分子,如Smad、ROCK、P38MAPK等可以减轻或预防滤过道瘢痕化,提高手术成功率。本文综述影响滤过道瘢痕化的主要信号传导通路以及针对不同通路进行干预的化学药物和基因治疗的研究进展。

A major cause of the failure in the filtration surgery of glaucoma lies in the postoperative scarring process.The transdifferentiation of fibroblasts to myofibroblasts is an'activat-ed'fibroblast phenotype with increased synthesis of extracellular matrix proteias.The function of many cellular factors is a crucial step in wound healing and scarring and is required for subsequent tissue remodeling.Via TGF-β/Smad,Rho-ROCK,MAPK and NF-κB signal transduction pathways,many cytokines mediate the scarring process.It is possible to prevent the process by making use of methods such as RNA inference to regulate of some key targets,such as Smad,ROCK P38MAPK.In this review,we summarized the primary signal transduction pathways in scarring after filtration surgery,and some ta rgeting mediators.